Signaling mechanisms that regulate smooth muscle cell differentiation.
Signaling mechanisms that regulate smooth muscle cell differentiation.
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DOI：
10.1161/atvbaha.110.221135
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发表时间：
2011-07
期刊：
影响因子：
--
通讯作者：
Mack CP
中科院分区：
文献类型：
--
作者：
Mack CP
过去30年的广泛研究表明，血管平滑肌细胞(SMC)的分化和表型调整受一系列动态的环境线索控制。由于我们对调控SMC特异性基因表达的转录机制了解不完全，因此识别这些环境信号调节SMC表型的信号机制变得更加困难。然而，这一领域的最新进展提供了重要的洞察力，本综述的目的是总结外部线索控制SMC分化的信号机制。
Extensive studies over the last 30 years have demonstrated that vascular smooth muscle cell (SMC) differentiation and phenotypic modulation is controlled by a dynamic array of environmental cues. The identification of the signaling mechanisms by which these environmental cues regulate SMC phenotype has been more difficult because of our incomplete knowledge of the transcription mechanisms that regulate SMC-specific gene expression. However, recent advances in this area have provided significant insight, and the goal of this review is to summarize the signaling mechanisms by which extrinsic cues control SMC differentiation.