Biocompatibility: its future in prosthodontic research.
Biocompatibility: its future in prosthodontic research.
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生物相容性：修复研究的未来。
DOI：
10.1016/0022-3913(93)90190-y
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发表时间：
1993
期刊：
影响因子：
--
通讯作者：
Levine,MJ
中科院分区：
文献类型：
--
作者：
Edgerton,M;Levine,MJ
口腔修复研究的未来将涉及通过使用科学方法来替换丢失的组织，这些方法基于所需的生物结果来评估生物材料和治疗设计。本发明的生物相容性材料的概念是在特定应用中激发适当的宿主反应的材料。为了设计最佳的生物材料，应考虑三个相互作用的组成部分：表面的化学性质，介导薄膜层，微生物和宿主的反应。表面化学决定了哪些分子从口腔液中选择性地吸附到表面上。薄膜涂层表面应设计成引起更理想的宿主反应。通过化学改变表面，用生物分子预涂表面，或使用旨在模拟天然组织的合成材料，可以改变薄膜的组成。一些表面敏感的技术可用于评估这些修改，包括振动光谱，电子显微镜化学分析，和生物分析方法。为了开发更多的生物相容性材料，进一步了解薄膜的形成作为一个功能的表面组成，微生物粘附到生物材料，和细胞反应植入生物材料是必要的。这方面的知识将有助于发展新的生物学为基础的理据治疗方式在牙科修复。
The future of prosthodontic research will involve replacing lost tissues by using scientific methods that evaluate biomaterials and treatment designs based on desired biologic outcomes. The present concept of a biocompatible material is one that elicits an appropriate host response in a specific application. To design optimal biomaterials, three interactive components should be considered: the chemical nature of the surface, the mediating pellicle layer, and microbial and host response. Surface chemistry determines which molecules are selectively adsorbed onto a surface from oral fluids. The pellicle-coated surface should be designed to elicit a more desirable host response. Pellicle composition can be altered by chemically changing the surface, precoating surfaces with biological molecules, or using synthetic materials designed to mimic natural tissues. Several surface-sensitive techniques are available to assess these modifications, including vibrational spectroscopy, electron microscopy for chemical analysis, and bioanalytical methods. To develop more biocompatible materials, a further understanding of pellicle formation as a function of surface composition, microbial adhesion to biomaterials, and cellular reaction to implant biomaterials is necessary. This knowledge will facilitate development of new biologically based rationales for treatment modalities in restorative dentistry.