An adhesive secreted by Australian frogs of the genus Notaden
An adhesive secreted by Australian frogs of the genus Notaden
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DOI：
10.1007/978-3-540-31049-5_11
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发表时间：
2006-01-01
期刊：
影响因子：
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通讯作者：
Ramshaw, John A. M.
中科院分区：
文献类型：
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作者：
Graham, Lloyd D.;Glattauer, Veronica;Ramshaw, John A. M.
对两栖动物皮肤分泌物的研究主要是针对各种两栖动物颗粒分泌物的各种毒性，药理，抗菌和毒性的生物活性化合物。两栖动物的皮肤和其他脊椎动物的皮肤有一个非常重要的区别，那就是所发现的腺结构的多样性。在两栖动物皮肤的分泌物中发现了显著的生物活性。例如，30多年来对澳大利亚青蛙皮肤的药理活性测试表明，存在大量简单和复杂的脂肪族、芳香族和杂环分子，以及一系列小肽和大肽（Doyle et al. 2003; Apponyi et al. 2004）。关于黏合剂渗出物的研究很少。这一领域的研究之所以缺乏，是因为很难将粘接腺产品放入溶液中进行分析（Williams 1994），尽管这些两栖动物的粘合剂通常似乎不需要共价固化步骤来获得粘合的韧性。Brodie和Gibson（1969）无法分析蝾螈（Ambystoma gracile）的颗粒状腺体分泌物，因为粘连分泌物难以溶解。Williams和Larsen（1986）用组织学方法证明了大dactyum的黏附分泌物是蛋白质。最近，Williams（1994）研究了三种已知会分泌粘合剂的蝾螈的分泌物。在水上和水下刺激动物发现，皮肤分泌物只有在暴露于空气中时才会变得粘连。Evans和Brodie（1994）还研究了12种两栖动物（包括5种青蛙）黏附分泌物的抗拉强度。分泌具有粘性的分泌物的青蛙包括来自南非的一种蛙，Breviceps poweri （Channing 2001）。
The main body of research into skin secretions from amphibians has been directed towards biologically active compounds responsible for the various toxic, pharmacological, antimicrobial and poisonous nature of various amphibian granular secretions. A very important difference between amphibian skin and that of other vertebrates is the diversity of glandular structures that are found. Significant bioactivity has been found within the secretions of amphibious skins. For example, pharmacological activity testing of Australian frog skins over a period of more than 30 years has shown the presence of an extensive array of simple and complex aliphatic, aromatic and heterocyclic molecules, as well as a range of small and large peptides (Doyle et al. 2003; Apponyi et al. 2004).There has been little research into adhesive exudates. The scarcity of research in this area has been attributed to the difficulty of getting the adhesive gland products into a solution for analysis (Williams 1994), even though the adhesives of these amphibians generally do not seem to entail a covalent curing step to give tenacity of adhesion. Brodie and Gibson (1969) were unable to analyze the granular gland secretions of a salamander, Ambystoma gracile, due to difficulties in dissolving the adhesive secretions. Williams and Larsen (1986) used histological methods to show that the adhesive secretions from A. macrodactylum were proteinaceous. More recently, Williams (1994) examined the secretions of three species of salamander known to secrete an adhesive. Stimulating the animals both above and under water revealed that the skin secretions only became adhesive when exposed to air. Also, Evans and Brodie (1994) examined the tensile strength of the adhesive secretions from 12 species of amphibian, including 5 frog species. Frogs that produce secretions with tenacious adhesive properties include those from a South African species, Breviceps poweri (Channing 2001).