Role of serotonergic neurons in the maintenance of the 10-Hz rhythm in sympathetic nerve discharge.
Role of serotonergic neurons in the maintenance of the 10-Hz rhythm in sympathetic nerve discharge.
复制标题
血清素能神经元在维持交感神经放电中 10 Hz 节律中的作用。
DOI：
10.1152/ajpregu.1996.270.1.r174
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发表时间：
1996
期刊：
影响因子：
--
通讯作者：
McCall,RB
中科院分区：
文献类型：
--
作者：
Orer,HS;Clement,ME;Barman,SM;Zhong,S;Gebber,GL;McCall,RB
我们研究了5-羟色胺（5-HT）受体激动剂和拮抗剂对交感神经放电（SND）中自然发生的10 Hz节律的影响。静脉注射5-HT 1A受体激动剂8-羟基-2-（二正丙基氨基）-四氢萘（8-OH-DPAT）和U-93385 E（可抑制延髓中缝神经元的放电）可降低SND 10 Hz频段的功率，但不影响频率≤ 6 Hz的功率。8-OH-DPAT和U-93385 E的抑制作用可被5-HT 1A受体拮抗剂spiperone和WAY-100135逆转。向延髓中缝核内微量注射8-OH-DPAT也可选择性地消除SND的10-Hz节律。静脉注射5-HT_2受体拮抗剂麦角新碱可阻断SND的10 Hz节律，而5-HT_2受体激动剂1-（2，5-二甲氧基-4-碘苯基）-2-氨基丙烷可增加SND 10 Hz频段的峰值频率和功率。向延髓中缝注射N-甲基-D-天冬氨酸也可增强SND的10-Hz节律。这些数据支持的观点，自然发生的放电的肾上腺素能延髓中缝神经元优先增强10 Hz的节奏在SND。
We studied the effects of serotonin (5-HT)-receptor agonists and antagonists on the naturally occurring 10-Hz rhythm in sympathetic nerve discharge (SND) of urethan-anesthetized, baroreceptor-denervated cats. Intravenous doses of the 5-HT1A-receptor agonists 8-hydroxy-2(di-n-propylamino)-tetralin (8-OH-DPAT) and U-93385E, which inhibit the firing of serotonergic medullary raphe neurons, decreased the power in the 10-Hz band of SND without affecting the power at frequencies < or = 6 Hz. The inhibitory effects of 8-OH-DPAT and U-93385E were reversed by the 5-HT1A-receptor antagonists spiperone and WAY-100135. Microinjection of 8-OH-DPAT into medullary raphe nuclei also selectively eliminated the 10-Hz rhythm in SND. Intravenous administration of the 5-HT2-receptor antagonist methysergide blocked the 10-Hz rhythm in SND, whereas the 5-HT2-receptor agonist 1-(2,5-dimethoxy-4-iodophenyl)-2-amino-propane increased peak frequency and power in the 10-Hz band of SND. Microinjection of N-methyl-D-aspartic acid into the medullary raphe also enhanced the 10-Hz rhythm in SND. These data support the view that the naturally occurring discharges of serotonergic medullary raphe neurons preferentially enhance the 10-Hz rhythm in SND.