Quantification of anion and cation release from a range of ternary phosphate-based glasses with fixed 45 mol% P2O5
Quantification of anion and cation release from a range of ternary phosphate-based glasses with fixed 45 mol% P2O5
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DOI：
10.1177/0885328205049396
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发表时间：
2005-07-01
影响因子：
2.9
通讯作者：
Knowles, JC
中科院分区：
文献类型：
--
作者：
Ahmed, I;Lewis, MP;Knowles, JC
本文报道了使用离子色谱法（IC）广泛调查的阳离子和阴离子的释放曲线和表征的三元基Na 2 O-CaO-P2 O 5玻璃系统开发的生物材料的组成和降解之间的关系。用累积释放法研究了45 P（2）O（5）-55（xCaO-Na_2 O）玻璃在去离子水中的降解行为，其中x = 30、35和40mol%，降解速率随CaO含量的增加而降低，降解速率与时间呈线性关系。然后，该速率随着CaO的进一步添加而增加。阳离子释放曲线遵循与降解速率相似的趋势。阴离子释放曲线显示，随着CaO含量的增加，PO 4和线性聚磷酸盐（P2 O 7和P3 O 10）物种减少。这种降低归因于Ca 2+离子的交联。相比之下，环状P3 O 9阴离子表现出最高量的阴离子释放，其表现出与阳离子类似的趋势。这些释放模式表明，循环P309物种占主导地位的降解速率。提出的降解模式是水解反应，环状偏磷酸盐进行酸/碱催化。对于30和35摩尔%的CaO玻璃，pH保持恒定，而对于40摩尔%的组合物，pH下降至约5.5。通过使用响应因子，可以半定量分析色谱图中观察到的其他峰。还提出了一些建议，这些未识别的峰的身份。
This article reports on the use of ion chromatography (IC) to investigate extensively the release profiles of both cations and anions and characterize the relationship between composition and degradation for a ternary-based Na2O-CaO-P2O5 glass system developed as biomaterials. Studies are carried out on glasses with the formula 45P(2)O(5)-55(xCaO-Na2O) in deionized water, where x = 30, 35, and 40 mol%, using a cumulative release method, where the solution is changed at regular intervals.Degradation behavior is linear with time where the degradation rate shows an initial decrease with increasing CaO content. This rate then increases with a further addition of CaO. Cation release profiles follow similar trends to the degradation rates. Anion release profiles show a decrease for the PO4 and linear polyphosphate (P2O7 and P3O10) species with increasing CaO content. This decrease is attributed to the cross-linking of the Ca2+ ions. In contrast, the cyclic P3O9 anion exhibits the highest amount of anionic release, which demonstrates similar trends to the cations. These release patterns suggest that the cyclic P309 species dominate the degradation rates. The proposed mode of degradation is a hydrolysis reaction, with the cyclic metaphosphate undergoing acid/ base catalysis. The pH remains constant for the 30 and 35 mol% CaO glasses, and drops to about 5.5 for the 40 mol% composition. By using a response factor, it is possible to semiquantitatively analyze the additional peaks observed in the chromatograms. Suggestions are also put forward as to the identity of some of these unidentified peaks.