Association Between Erosive Esophagitis and Visceral Fat Accumulation Quantified by Abdominal CT Scan
Association Between Erosive Esophagitis and Visceral Fat Accumulation Quantified by Abdominal CT Scan
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DOI：
10.1097/mcg.0b013e318167b88a
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发表时间：
2009-03-01
影响因子：
2.9
通讯作者：
Song, Soon Young
中科院分区：
文献类型：
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作者：
Lee, Hang Lak;Eun, Chang Soo;Song, Soon Young
背景和目的：目前还没有关于糜烂性食管炎和腹部脂肪之间关系的客观数据。我们进行了这项研究，以检查腹部脂肪和胃食管反流病相关的糜烂性食管炎。方法：2004年5月至2005年10月，共100例糜烂性食管炎患者诊断上消化道内镜进行了前瞻性的方式进行了评估。所有研究患者和对照组均接受腹部计算机断层扫描（CT）。通过CT在第四腰椎骨水平上使用10 mm厚的切片评估体脂分布。结果：侵蚀性食管炎患者的平均内脏脂肪（VF）面积（104.68 +/- 39.47 vs. 75.90 +/- 49.10 cm（2），P = 0.014）明显高于对照组。然而，糜烂性食管炎与皮下脂肪面积（109.72 +/- 49.09 vs. 98.66 +/-52.43 cm（2），P = 0.379）或总脂肪面积（214.41 +/- 78.78 vs. 172.59 +/- 90.49 cm（2），P = 0.054）之间没有关联。多因素Logistic回归分析显示，高VF区（P = 0.0035），VF/皮下脂肪面积（P = 0.005），食管裂孔疝（P = 0.001）高体重指数（P = 0.047）高腰臀比（P = 0.042），吸烟（P = 0.005）是糜烂性食管炎的独立危险因素。这些结果表明，内脏肥胖的作用，量化CT，作为糜烂性食管炎的危险因素。
Background and Aims: There were no objective data presented about the association between erosive esophagitis and abdominal fat. We conducted this study to examine the association of abdominal fat and gastroesophageal reflux disease-related erosive esophagitis.Methods: Between May 2004 and October 2005, a total of 100 erosive esophagitis patients diagnosed by upper endoscopy were evaluated in a prospective manner. All study patients and controls underwent abdominal computed tomography (CT) scan. Body fat distribution was assessed by CT with a 10-mm-thick slice at the level of the fourth lurnbar vertebra.Results: Erosive esophagilis patients presented with a significantly higher mean visceral fat (VF) area (104.68 +/- 39.47 vs. 75.90 +/- 49.10 cm(2), P = 0.014) than the control group. However, there was no association between erosive esophagitis and subcutaneous fat area (109.72 +/- 49.09 vs. 98.66 +/- 52.43cm(2), P = 0.379) or total fat area (214.41 +/- 78.78 vs. 172,59 +/- 90.49 cm(2), P = 0.054). Multivariate logistic regression analysis demonstrated that high VF areas (P = 0.0035), VF/subcutaneous fat area (P = 0.005), hiatal hernia (P = 0.001) high body mass index (P = 0.047) high waist-to-hip ratio (P = 0.042), and smoking (P = 0.005) are independent risk factors of erosive esophagitis.Conclusions: These results suggest a role for visceral obesity, quantified by CT, as a risk factor for erosive esophagitis.