Specificity of Monosynaptic Sensory-Motor Connections Imposed by Repellent Sema3E-PlexinD1 Signaling
Specificity of Monosynaptic Sensory-Motor Connections Imposed by Repellent Sema3E-PlexinD1 Signaling
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DOI：
10.1016/j.celrep.2013.10.005
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发表时间：
2013-11-01
期刊：
影响因子：
8.8
通讯作者：
Yoshida, Yutaka
中科院分区：
文献类型：
--
作者：
Fukuhara, Kaori;Imai, Fumiyasu;Yoshida, Yutaka
在哺乳动物脊髓中，Ia 组本体感觉传入神经与一组选定的运动池目标形成选择性单突触连接。运动神经元的感觉识别在多大程度上有助于感觉运动连接的选择性仍不清楚。我们在这里表明，表达 PlexinD1 的本体感觉传入避免与 Sema3E(+) 运动池中的神经元形成单突触连接，但能够与 Sema3E(off) 运动池中的神经元形成直接连接。对 Sema3E-PlexinD1 信号传导失调或基因失活的小鼠进行解剖学和电生理学分析表明，驱避信号传导是这些反射弧中单突触感觉运动连接特异性的基础。因此，基于信号蛋白的运动神经元识别和排斥系统有助于哺乳动物脊髓中特定感觉运动连接的形成。
In mammalian spinal cord, group Ia proprioceptive afferents form selective monosynaptic connections with a select group of motor pool targets. The extent to which sensory recognition of motor neurons contributes to the selectivity of sensory-motor connections remains unclear. We show here that proprioceptive sensory afferents that express PlexinD1 avoid forming monosynaptic connections with neurons in Sema3E(+) motor pools yet are able to form direct connections with neurons in Sema3E(off) motor pools. Anatomical and electrophysiological analysis of mice in which Sema3E-PlexinD1 signaling has been deregulated or inactivated genetically reveals that repellent signaling underlies aspects of the specificity of monosynaptic sensory-motor connectivity in these reflex arcs. A semaphorin-based system of motor neuron recognition and repulsion therefore contributes to the formation of specific sensory-motor connections in mammalian spinal cord.