HERPES-SIMPLEX VIRUS PNEUMONIA - CLINICAL, VIROLOGIC, AND PATHOLOGIC FEATURES IN 20 PATIENTS
HERPES-SIMPLEX VIRUS PNEUMONIA - CLINICAL, VIROLOGIC, AND PATHOLOGIC FEATURES IN 20 PATIENTS
复制标题
DOI：
10.7326/0003-4819-97-6-813
复制
发表时间：
1982-01-01
影响因子：
39.2
通讯作者：
COREY, L
中科院分区：
文献类型：
--
作者：
RAMSEY, PG;FIFE, KH;COREY, L
单纯疱疹病毒（疱疹病毒）是从20例有肺炎临床、x线和组织学证据的尸检肺标本中分离出来的。17例患者发生肺炎前存在皮肤粘膜疱疹病毒感染。12例患者有局灶性肺炎，其中10例合并疱疹性气管炎、食管炎或两者兼有。8例患者有弥漫性间质性肺炎，其中6例有疱疹病毒向其他器官传播。8株肺分离株中，7株为1型疱疹病毒，1株为2型疱疹病毒。在肺炎前获得的血清样本中疱疹病毒抗体的高流行率以及个别患者中粘膜和肺分离物之间相同的限制性内切酶模式表明，在大多数情况下，疱疹病毒肺炎是由于病毒的内源性再激活。局灶性疱疹病毒肺炎似乎是由疱疹病毒连续传播到肺实质引起的；弥漫性间质性肺炎似乎是病毒血行传播的表现。
Herpes simplex virus (herpesvirus) was isolated from autopsy lung specimens of 20 patients with clinical, roentgenographic and histologic evidence of pneumonia. Mucocutaneous herpesvirus infection preceded the onset of pneumonia in 17 patients. Twelve patients had focal pneumonia, 10 of whom had concomitant herpetic tracheitis, esophagitis or both. Eight patients had diffuse interstitial pneumonia, 6 of whom had dissemination of herpesvirus to other organs. Of the 8 lung isolates available for typing, 7 were herpesvirus type 1 and one, herpesvirus type 2. A high prevalence of herpesvirus antibody in serum samples obtained before pneumonia and identical restriction endonuclease patterns between mucosal and lung isolates in individual patients indicated that, in most cases, herpesvirus pneumonia was due to endogenous reactivation of virus. Focal herpesvirus pneumonia appeared to result from contiguous spread of herpesvirus to lung parenchyma; diffuse interstitial pneumonia appeared to be a manifestation of hematogenous dissemination of virus.