Enhanced blood pressure responses to loud noise in offspring of monkeys with high blood pressure.
Enhanced blood pressure responses to loud noise in offspring of monkeys with high blood pressure.
复制标题
高血压猴子的后代对大声噪音的血压反应增强。
DOI：
10.1016/0031-9384(84)90194-x
复制
发表时间：
1984
影响因子：
2.9
通讯作者：
Rodger,RF
中科院分区：
文献类型：
--
作者：
Kirby,DA;Herd,JA;Hartley,LH;Teller,DD;Rodger,RF
16只18-43月龄未麻醉的未成熟食蟹猴对30分钟连续宽带噪声（95 dB）的平均动脉血压（MBP）和心率（HR）反应进行了测试。8只（OH组）为高血压猴的后代（父母的MBP=115.5±1.0（SEM）mmHg），8只（OC组）为正常血压对照动物的后代（父母的MBP=96.6±1.7 mmHg）。在实验前17-24小时期间，OH组的静息MBP为100.6±1.9 mmHg，显著高于OC组的MBP（94.3±2.2 mmHg）（p<0.05）。在噪声暴露之前，OH组的MBP稳定30分钟，为104±3 mmHg。在噪声暴露期间，MBP显著升高至108±4 mmHg。在OC组中，30 min基线间期的MBP为95±2 mmHg，噪声暴露期间的MBP无显著变化，为94±3 mmHg。OC组在噪声期间心率显著降低，OH组没有变化。结果表明，患有高血压的猴子的后代具有比对照动物更高的静息MBP，并且在对巨大噪音的反应中表现出显着的MBP增加。对照组动物的MBP没有变化，HR对噪音的反应也没有降低。
Sixteen unanesthetized immature Macaca fascicularis monkeys, 18–43 months of age, were tested for mean arterial blood pressure (MBP) and heart rate (HR) responses to 30 minutes of continuous broadband noise (95 dB). Eight animals (OH group) were offspring of monkeys with high blood pressure (parents' MBP=115.5±1.0 (SEM) mmHg), and eight (OC group) were offspring of control animals with normal blood pressure (parents' MBP=96.6±1.7 mmHg). Resting MBP during a 17–24 hour period prior to the experiment in the OH group was 100.6±1.9 mmHg, significantly higher (p<0.05) than the MBP of the OC group (94.3±2.2 mmHg.) Immediately prior to noise exposure, MBP in the OH group was stable for 30 minutes, at 104±3 mmHg. During noise exposure, MBP increased significantly to 108±4 mmHg. In the OC group, MBP during the 30 min baseline interval was 95±2 mmHg, and during noise exposure was not significantly changed at 94±3 mmHg. Heart rate decreased significantly during noise in the OC group and did not change in the OH group. The results indicate that the offspring of monkeys with high blood pressure had higher resting MBP than control animals and showed significant MBP increases in response to loud noise. Control animals showed no change in MBP and decreases in HR in response to noise.