The Challenge of Causal Inference in Gene-Environment Interaction Research: Leveraging Research Designs From the Social Sciences
The Challenge of Causal Inference in Gene-Environment Interaction Research: Leveraging Research Designs From the Social Sciences
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DOI：
10.2105/ajph.2013.301290
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发表时间：
2013-10-01
影响因子：
12.7
通讯作者：
Conley, Dalton
中科院分区：
文献类型：
--
作者：
Fletcher, Jason M.;Conley, Dalton
遗传学和社会科学的整合将导致对社会和生物过程之间的衔接的更复杂的理解，尽管这种整合所固有的经验困难很大。一个关键的挑战是“走出实验室”，远离可用于模式生物研究的实验工具的影响。迄今为止，用于在非实验的、现实世界的环境中检验人类行为的社会科学研究方法，在这一学科整合过程中，特别是在基因-环境相互作用研究的形式中，还没有得到充分利用。这篇文章概述并提供了几个应该用于基因环境研究的突出研究设计的例子，并强调了遗传学家与社会科学家合作的一个关键好处。
The integration of genetics and the social sciences will lead to a more complex understanding of the articulation between social and biological processes, although the empirical difficulties inherent in this integration are large.One key challenge is the implications of moving "outside the lab" and away from the experimental tools available for research with model organisms. Social science research methods used to examine human behavior in nonexperimental, real-world settings to date have not been fully taken advantage of during this disciplinary integration, especially in the form of gene-environment interaction research.This article outlines and provides examples of several prominent research designs that should be used in gene-environment research and highlights a key benefit to geneticists of working with social scientists.