Epidermotropic precursor T-cell lymphoma with highly aggressive clinical behavior simulating localized pagetoid reticulosis.
Epidermotropic precursor T-cell lymphoma with highly aggressive clinical behavior simulating localized pagetoid reticulosis.
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亲表皮性前体 T 细胞淋巴瘤，具有高度侵袭性的临床行为，类似于局限性佩吉样网织组织增生症。
DOI：
10.1097/dad.0b013e31812f51b7
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发表时间：
2007
期刊：
影响因子：
--
通讯作者：
L. Cerroni
中科院分区：
文献类型：
--
作者：
B. Leinweber;A. Chott;H. Kerl;L. Cerroni
我们描述了一名 43 岁的患者，其右侧乳头上有一个孤立的湿疹斑块，该斑块是在过去 6 周内形成的。组织病理学显示表面有中等至大型多形性淋巴细胞的带状浸润，具有显着的亲表皮性。肿瘤细胞表达 T 表型（CD3+、CD20-）并且为 CD30-、CD4- 和 CD8- 阴性。提出了局限性佩吉样网状细胞增多症（沃林格-科洛普病）的诊断，可能伴有大细胞转化。两个月后切除的颈部淋巴结显示出高度侵袭性母细胞前体 T 细胞淋巴瘤的特征。对皮肤病变和先前被解释为良性增生的扁桃体标本的重新评估显示出与淋巴结中观察到的特征一致的特征。该疾病进展迅速，患者在第一次皮肤活检后 15 个月死亡。该病例代表了侵袭性前驱淋巴瘤的独特皮肤表现，显示了淋巴增殖性疾病的多变性质以及不同实体的重叠临床和组织病理学特征。
We describe a 43-year-old patient with a solitary, eczematous plaque on his right nipple that had developed during the previous 6 weeks. Histopathology revealed a superficial band-like infiltrate of medium to large-sized pleomorphic lymphocytes with striking epidermotropism. The tumor cells expressed a T-phenotype (CD3+, CD20-) and were CD30-, CD4-, and CD8-negative. A diagnosis of localized pagetoid reticulosis (Woringer-Kolopp disease) with possible large cell transformation was proposed. A cervical lymph node excised 2 months later showed features of a highly aggressive blastoid precursor T-cell lymphoma. Reevaluation of the skin lesion and of a tonsil specimen previously interpreted as benign hyperplasia showed features consistent with those observed in the lymph node. The disease was rapidly progressive, and the patient died 15 months after the first skin biopsy. This case represents a unique cutaneous presentation of aggressive precursor lymphoma, showing the protean nature of lymphoproliferative disorders and the overlapping clinical and histopathologic features of different entities.