Supercritical carbon dioxide-assisted drug loading and release from biocompatible porous metal-organic frameworks
Supercritical carbon dioxide-assisted drug loading and release from biocompatible porous metal-organic frameworks
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DOI：
10.1039/c4tb00725e
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发表时间：
2014-01-01
影响因子：
7
通讯作者：
Okuyama, Tetsuya
中科院分区：
文献类型：
--
作者：
Matsuyama, Kiyoshi;Hayashi, Nobukatsu;Okuyama, Tetsuya
本文中，我们描述了超临界二氧化碳（scCO（2））辅助的药物从无毒且生物相容的多孔铁（III）聚羧酸盐金属有机框架（MOF）的负载和释放，其表现出非常高的货物负载和逐渐释放。MIL-53（Fe）和MIL-100（Fe）作为药物分子的潜在载体进行了研究，使用布洛芬作为模型药物候选物。通过热重分析（TGA）和高效液相色谱（HPLC）测量来监测布洛芬的负载和释放行为，以定量地确定布洛芬的摄取，并且首次使用基于scCO（2）的技术进行。在特定溶剂中制备MOF后，由于scCO（2）干燥方法，MIL-53（Fe）和MIL-100（Fe）的内表面积增加。此外，布洛芬可以通过利用scCO（2）-己烷溶液浸渍到MOFs的孔中。ScCO 2辅助的浸渍也可用于将布洛芬递送到MOF的孔中。结果，大量的布洛芬能够负载到MIL-53（Fe）和MIL-100（Fe）中。
Herein we describe the supercritical carbon dioxide (scCO(2))-assisted drug loading and release from nontoxic and biocompatible porous iron(III) polycarboxylate metal-organic frameworks (MOFs), which exhibited very high cargo loadings and gradual release. MIL-53(Fe) and MIL-100(Fe) were investigated as potential carriers for drug molecules, using ibuprofen as a model drug candidate. The loading and release behaviour of ibuprofen were monitored by thermogravimetric analyses (TGA) and high performance liquid chromatography (HPLC) measurements to quantitatively determine the ibuprofen uptake, and have been performed for the first time using scCO(2)-based technology. After the preparation of the MOFs within a particular solvent, the internal surface area of MIL-53(Fe) and MIL-100(Fe) increased as a result of the scCO(2) drying method. Furthermore, ibuprofen could be impregnated into the pores of the MOFs by utilizing a scCO(2)-hexane solution. ScCO2-assisted impregnation could also be used to deliver ibuprofen to the pores of the MOFs. As a result, a large amount of ibuprofen was able to be loaded into MIL-53(Fe) and MIL-100(Fe).