ULTRASMALL SUPERPARAMAGNETIC IRON-OXIDE - AN INTRAVENOUS CONTRAST AGENT FOR ASSESSING LYMPH-NODES WITH MR IMAGING
ULTRASMALL SUPERPARAMAGNETIC IRON-OXIDE - AN INTRAVENOUS CONTRAST AGENT FOR ASSESSING LYMPH-NODES WITH MR IMAGING
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DOI：
10.1148/radiology.175.2.2326475
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发表时间：
1990-05-01
期刊：
影响因子：
19.7
通讯作者：
BRADY, TJ
中科院分区：
文献类型：
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作者：
WEISSLEDER, R;ELIZONDO, G;BRADY, TJ
一种超小型超顺磁性氧化铁（USPIO）制剂被评价为潜在的淋巴结静脉造影剂。对淋巴结正常大鼠和淋巴结转移大鼠进行松弛时间测量和磁共振成像。在正常动物中，静脉注射USPIO后24-48小时内淋巴结松弛时间最大。给药24小时后，正常淋巴结T2由74 msec +-下降。2.2至30毫秒。0.7 （USPIO, 40 .mu）摩尔铁每千克)或15毫秒+-。0.0（200 .亩）mol Fe/kg)，而转移淋巴结T2无变化。淋巴结转移动物模型的MR成像证实了静脉注射USPIO降低正常而非转移淋巴结的信号强度的假设。单次静脉注射USPIO可以根据信号强度特征而不是目前使用的不敏感的大小特征来检测淋巴结转移。
An ultrasmall superparamagnetic iron oxide (USPIO) preparation was evaluated as a potential intravenous contrast agent for lymph nodes. Relaxation time measurements and magnetic resonance (MR) imaging were performed in rats with normal lymph nodes and in rats with lymph nodes metastases. In normal animals, lymph node relaxation times decreased maximally within 24-48 hours after intravenous administration of USPIO. Twenty-four hours after administration, the T2 of normal lymph nodes had decreased from 74 msec .+-. 2.2 to 30 msec .+-. 0.7 (USPIO, 40 .mu.mol of iron per kilogram) or 15 msec .+-. 0.0 (200 .mu.mol Fe/kg), whereas the T2 of metastatic nodes did not change. MR imaging of the animal model of nodal metastases confirmed the hypothesis that intravenously administered USPIO decreases signal intensity of normal but not metastatic nodes. A single intravenous administration of USPIO may allow detection of nodal metastases on the basis of signal intensity characteristics rather than the currently used, insensitive size characteristics.