DIVERSITY OF MURINE GAMMA GENES AND EXPRESSION IN FETAL AND ADULT LYMPHOCYTES-T
DIVERSITY OF MURINE GAMMA GENES AND EXPRESSION IN FETAL AND ADULT LYMPHOCYTES-T
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DOI：
10.1038/322836a0
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发表时间：
1986-08-28
期刊：
影响因子：
64.8
通讯作者：
TONEGAWA, S
中科院分区：
文献类型：
--
作者：
HEILIG, JS;TONEGAWA, S
对编码t细胞受体α和β链的基因的搜索揭示了第三个基因，Tγ（参考文献）。1)，它与Tα（参考文献2-7）和Tβ（参考文献8-15）基因共享许多结构特征，包括t细胞发育过程中的体细胞重排。T- γ基因的表达在一些成熟的T细胞中似乎是不必要的16,17，在胎儿胸腺细胞中表达最多18,19，这鼓励了人们的猜测，即T- γ在T细胞发育中起作用，并可能参与胸腺发育过程中多态性主要组织相容性复合体（MHC）产物的识别20,21。反对t - γ参与这一过程的一种观点是，由于可用于重排的基因片段数量较少，其多样性明显有限。我们在此描述了额外的t γ - v基因片段的鉴定，并证明它们可以重排到先前鉴定的J-和c -基因片段，并在胎儿胸腺细胞中表达。此外，我们还描述了多种可能对t - γ基因调控有重要意义的t - γ mrna加工模式。
The search for the genes encoding the T-cell receptorαandβchains revealed a third gene, Tγ(ref. 1), which shares with the Tα(refs 2–7) and Tβ(refs 8–15) genes a number of structural features, including somatic rearrangement during T-cell development. Tγgene expression appears to be unnecessary in some mature T cells16,17and is at its greatest in fetal thymocytes18,19, encouraging speculation that Tγhas a role in T-cell development and may be involved in the recognition of polymorphic major histocompatibility complex (MHC) products during thymic education20,21. One argument against the participation of Tγin such a process has been its apparently limited diversity, due to the small number of gene segments available for rearrangement1,22. We here describe the identification of additional TγV-gene segments and demonstrate that they can be rearranged to previously identified J- and C-gene segments and are expressed in fetal thymocytes. In addition we describe a variety of patterns of TγmRNA processing which may be significant for Tγgene regulation.