THYMIDINE INCORPORATION IN THE OLFACTORY EPITHELIUM OF MICE - EARLY EXPONENTIAL RESPONSE INDUCED BY OLFACTORY NEURECTOMY
THYMIDINE INCORPORATION IN THE OLFACTORY EPITHELIUM OF MICE - EARLY EXPONENTIAL RESPONSE INDUCED BY OLFACTORY NEURECTOMY
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DOI：
10.1016/0006-8993(84)90917-x
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发表时间：
1984-01-01
期刊：
影响因子：
2.9
通讯作者：
HARDING, JW
中科院分区：
文献类型：
--
作者：
CAMARA, CG;HARDING, JW
神经切片后，嗅上皮的[3]胸苷掺入量立即呈指数级上升，在第4天达到对照值的12倍峰值，到第10天下降速度稍慢，接近对照水平。上皮细胞的蛋白质含量降低至约0.01%。在第3天达到对照水平的50%，然后线性增加，并在第10天达到对照值。这些数据与嗅神经切片后嗅上皮细胞的快速损失一致，这与基底细胞群的促有丝分裂活性显著增加一致。
The incorporation of [3]thymidine by the olfactory epithelium rises exponentially immediately after nerve section, reaches a peak 12-fold over control values at day 4, and decreases somewhat less rapidly to near control levels by day 10. The protein content of the epithelium decreased to .apprx. 50% of control levels at day 3, then increased linearly and reached control values by day 10. These data are consistent with a rapid loss of cells from the olfactory epithelium following olfactory nerve section that is coincident with a marked increase in the mitogenic activity of the basal cell population.