Whole-brain ex-vivo quantitative MRI of the cuprizone mouse model.
Whole-brain ex-vivo quantitative MRI of the cuprizone mouse model.
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作者：
Wood TC;Simmons C;Hurley SA;Vernon AC;Torres J;Dell'Acqua F;Williams SC;Cash D
髓磷脂是神经系统的重要组成部分，也是磁共振 (MR) 图像对比度的主要贡献者。然而，髓鞘形成对多种 MR 模式的确切贡献仍存在争议。 cuprizone 小鼠是一种成熟的脱髓鞘模型，已用于多项 MR 研究，但这些研究通常仅对单个切片进行成像并分析胼胝体中的一小部分感兴趣区域。我们使用高分辨率定量 MR 方法（多分量松弛测量、弥散张量成像 (DTI) 和形态测量）对 cuprizone 小鼠的整个大脑进行离体成像和分析，发现多个区域的变化，包括胼胝体、小脑、丘脑和海马。经组织学证实的炎症的存在，在使用该模型分离这些 MR 方法对脱髓鞘的敏感性和特异性方面存在困难。
Myelin is a critical component of the nervous system and a major contributor to contrast in Magnetic Resonance (MR) images. However, the precise contribution of myelination to multiple MR modalities is still under debate. The cuprizone mouse is a well-established model of demyelination that has been used in several MR studies, but these have often imaged only a single slice and analysed a small region of interest in the corpus callosum. We imaged and analyzed the whole brain of the cuprizone mouse ex-vivo using high-resolution quantitative MR methods (multi-component relaxometry, Diffusion Tensor Imaging (DTI) and morphometry) and found changes in multiple regions, including the corpus callosum, cerebellum, thalamus and hippocampus. The presence of inflammation, confirmed with histology, presents difficulties in isolating the sensitivity and specificity of these MR methods to demyelination using this model.
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影响因子：
3.1
作者：
Goldberg, Johannes;Clarner, Tim;Kipp, Markus
通讯作者：
Kipp, Markus
影响因子：
4.4
作者：
Deoni, Sean C. L.
通讯作者：
Deoni, Sean C. L.
影响因子：
3.3
作者：
Bouhrara, Mustapha;Reiter, David A.;Spencer, Richard G.
通讯作者：
Spencer, Richard G.
影响因子：
5.7
作者：
Guglielmetti C;Veraart J;Roelant E;Mai Z;Daans J;Van Audekerke J;Naeyaert M;Vanhoutte G;Delgado Y Palacios R;Praet J;Fieremans E;Ponsaerts P;Sijbers J;Van der Linden A;Verhoye M
通讯作者：
Verhoye M
影响因子：
5.7
作者：
Avants BB;Tustison NJ;Song G;Cook PA;Klein A;Gee JC
通讯作者：
Gee JC