Optimizing Mouse Surgery with Online Rectal Temperature Monitoring and Preoperative Heat Supply. Effects on Post-Ischemic Acute Kidney Injury
Optimizing Mouse Surgery with Online Rectal Temperature Monitoring and Preoperative Heat Supply. Effects on Post-Ischemic Acute Kidney Injury
复制标题
DOI：
10.1371/journal.pone.0149489
复制
发表时间：
2016-02-18
期刊：
影响因子：
3.7
通讯作者：
Anders, Hans-Joachim
中科院分区：
文献类型：
--
作者：
Marschner, Julian A.;Schaefer, Hannah;Anders, Hans-Joachim
体温影响组织损伤的结果。我们假设在线体温记录和选择性干预有助于规范实验性肾缺血再灌注损伤（IRI）的介入期体温控制和结果的可靠性。我们使用Thermes USB记录仪和ret-3-iso直肠探针以三种不同的方式同时记录了多达7只小鼠的核心温度。设置A：缺血时加热垫；装置B：从切口到伤口闭合的加热垫；设置C：手术前和缺血期间在加热垫上进行手术的通风加热室。体温记录显示安装麻醉后明显下降。基线实验设置A的轮廓显示
Body temperature affects outcomes of tissue injury. We hypothesized that online body core temperature recording and selective interventions help to standardize peri-interventional temperature control and the reliability of outcomes in experimental renal ischemia reperfusion injury (IRI). We recorded core temperature in up to seven mice in parallel using a Thermes USB recorder and ret-3-iso rectal probes with three different protocols. Setup A: Heating pad during ischemia time; Setup B: Heating pad from incision to wound closure; Setup C: A ventilated heating chamber before surgery and during ischemia time with surgeries performed on a heating pad. Temperature profile recording displayed significant declines upon installing anesthesia. The profile of the baseline experimental setup A revealed that