Estrogenic activity of phenolic additives determined by an in vitro yeast bioassay
Estrogenic activity of phenolic additives determined by an in vitro yeast bioassay
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DOI：
10.2307/3434765
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发表时间：
2001-02-01
影响因子：
10.4
通讯作者：
Sumpter, JP
中科院分区：
文献类型：
--
作者：
Miller, D;Wheals, BB;Sumpter, JP
我们使用重组酵母雌激素试验来评估73种酚类添加剂的活性，这些添加剂被用作防晒霜、防腐剂、消毒剂、抗氧化剂、调味剂或香水。其中32种化合物显示出活性：22种化合物的效力相对于17 β -雌二醇，范围从1/3,000到< 1/3,000,000,10种化合物的反应受损，不能直接与17-雌二醇相比。41个化合物无活性。活性的主要标准似乎是在对位上存在一个不受阻碍的酚OH基团，分子量为140-250 Da。
We used a recombinant yeast estrogen assay to assess the activity of 73 phenolic additives that are used as sunscreens, preservatives, disinfectants, antioxidants, flavorings, or for perfumery. Thirty-two of these compounds displayed activity: 22 with potencies relative to 17 beta -estradiol, ranging from 1/3,000 to < 1/3,000,000, and 10 compounds with an impaired response that could not be directly compared with 17-estradiol. Forty-one compounds were inactive. The major criteria for activity appear to be the presence of an unhindered phenolic OH group in a para position and a molecular weight of 140-250 Da.