Contrasting patterns of Y-chromosome variation in south Siberian populations from Baikal and Altai-Sayan regions
Contrasting patterns of Y-chromosome variation in south Siberian populations from Baikal and Altai-Sayan regions
复制标题
DOI：
10.1007/s00439-005-0076-y
复制
发表时间：
2006-01-01
期刊：
影响因子：
5.3
通讯作者：
Zakharov, I
中科院分区：
文献类型：
--
作者：
Derenko, M;Malyarchuk, B;Zakharov, I
为了研究南西伯利亚本土人群的遗传史并估计不同父系对其基因库的贡献，我们分析了 17 个 Y 染色体二元标记（YAP、RPS4Y(711)、SRY-8299、M89、M201、M52、M170、12f2、M9、M20、92R7、SRY-1532、 DYS199、M 173、M 17、Tat 和 LLY22 g），共 1,358 名男性样本，来自西伯利亚（阿尔泰-基日人、特鲁特人、绍尔斯人、图维尼亚人、托金人、托法拉人、索约特人、哈卡斯人、布里亚特人、鄂温克人）、中/东亚（蒙古人和朝鲜人）和东欧（卡尔梅克人和俄罗斯人）。基于Y染色体单倍群的分布模式和AMOVA分析结果，我们观察到贝加尔湖和阿尔泰-萨彦岭地区人群之间存在统计学上显着的遗传分化。我们认为，这些区域差异可以通过中亚/东亚和东欧父系谱系对现代南西伯利亚人基因库的不同贡献来最好地解释。贝加尔湖地区的人口显示出中亚/东亚血统的盛行，而在阿尔泰和萨彦地区的人口中，东欧血统的父系贡献最高。然而，我们关于 Y 染色体 STR 变异的数据表明，南西伯利亚和东欧 R1a1 谱系之间存在明显差异，其进化年龄与这两个区域群体之间的分化时间相一致。
In order to investigate the genetic history of autochthonous South Siberian populations and to estimate the contribution of distinct patrilineages to their gene pools, we have analyzed 17 Y-chromosomal binary markers (YAP, RPS4Y(711), SRY-8299, M89, M201, M52, M170,12f2, M9, M20,92R7, SRY-1532, DYS199, M 173, M 17, Tat, and LLY22 g) in a total sample of 1,358 males from 14 ethnic groups of Siberia (Altaians-Kizhi, Teleuts, Shors, Tuvinians, Todjins, Tofalars, Sojots, Khakassians, Buryats, Evenks), Central/Eastern Asia (Mongolians and Koreans) and Eastern Europe (Kalmyks and Russians). Based on both, the distribution pattern of Y-chromosomal haplogroups and results on AMOVA analysis we observed the statistically significant genetic differentiation between the populations of Baikal and Altai-Sayan regions. We suggest that these regional differences can be best explained by different contribution of Central/Eastern Asian and Eastern European paternal lineages into gene pools of modern South Siberians. The population of the Baikal region demonstrates the prevalence of Central/Eastern Asian lineages, whereas in the populations of Altai and Sayan regions the highest paternal contribution resulted from Eastern European descent is revealed. Yet, our data on Y-chromosome STRs variation demonstrate the clear differences between the South Siberian and Eastern European R1a1-lineages with the evolutionary ages compatible with divergence time between these two regional groups.