Effects of full-mouth scaling and root planing in conjunction with systemically administered azithromycin
Effects of full-mouth scaling and root planing in conjunction with systemically administered azithromycin
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DOI：
10.1902/jop.2007.060247
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发表时间：
2007-03-01
影响因子：
4.3
通讯作者：
Arai, Takashi
中科院分区：
文献类型：
--
作者：
Gomi, Kazuhiro;Yashima, Akihiro;Arai, Takashi
背景：1995年引入了一期全口消毒（FMD），即在辅助使用氯己定的情况下进行全口清洁和牙根规划（SRP）。已经有一些关于这种治疗方案有效性的报告。然而，口蹄疫经常引起发热。我们检查了全口SRP与SRP前口服阿奇霉素的效果，以控制细菌数量。本研究的目的是比较使用阿奇霉素的全口SRP与常规SRP的效果。方法：选择重度慢性牙周炎患者34例（试验组17例，对照组17例）。试验组患者在全口SRP前3天给予阿奇霉素治疗。临床参数（探诊深度[PD]、牙龈指数[GI]、探诊出血[BOP]、牙龈沟液[GCF]）、细菌总数、黑色色素生成杆（bpr）数量在基线及基线后5周、13周和25周进行评估。结果：试验组各项临床指标改善程度均高于对照组。在细菌学检查中，细菌总数在检查过程中没有变化。试验组13周后才检测到bpr。然而，对照组在13周时检测到bpr。结论：系统给予阿奇霉素全口治疗是治疗重度慢性牙周炎的一种临床和细菌学上有效的基础牙周治疗方法。
Background: One-stage full-mouth disinfection (FMD), in which full-mouth scaling and root planing (SRP) is performed with adjunctive use of chlorhexidine, was introduced in 1995. There have been several reports on the effectiveness of this treatment protocol. However, FMD was reported to induce pyrexia frequently. We examined the effects of full-mouth SRP in conjunction with azithromycin administered orally before SRP to control the number of bacteria. The purpose of this study was to compare the effects of full-mouth SRP using azithromycin with conventional SRP.Methods: Thirty-four subjects (17 in the test group and 17 in the control group) with severe chronic periodontitis were selected. The subjects of the test group had azithromycin 3 days before full-mouth SRP. Clinical parameters (probing depth [PD], gingival index [GI], bleeding on probing [BOP], and gingival crevicular fluid [GCF]), total number of bacteria, and number of black pigment-producing rods (BPRs) were evaluated at baseline and 5, 13, and 25 weeks after baseline.Results: All clinical parameters improved in the test group more than in the control group. In the bacteriologic examination, the total number of bacteria did not change during the examination. In the test group, BPRs were not detected until 13 weeks. However, BPRs were detected in the control group by 13 weeks.Conclusion: It was shown that full-mouth SRP using systemically administered azithromycin was a clinically and bacteriologically useful basic periodontal treatment for severe chronic periodontitis.