Lens thickness and five-year cumulative incidence of cataracts: The Beaver Dam Eye Study.
Lens thickness and five-year cumulative incidence of cataracts: The Beaver Dam Eye Study.
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DOI：
10.1076/opep.7.4.243.4176
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发表时间：
2000-12-01
影响因子：
1.8
通讯作者：
Moss, S E
中科院分区：
文献类型：
--
作者：
Klein, B E;Klein, R;Moss, S E
目得：评价透镜厚度是否与白内障发病率相关。方法：在比弗坝眼科研究中，通过裂隙灯拍摄的透镜照片测量透镜厚度。在基线和5年随访检查时，通过分级标准裂隙灯和透镜的后照照片确定白内障发病率。结果：透镜厚度与核性白内障发病率呈正相关，与皮质性白内障发病率呈负相关，且与年龄、性别、糖尿病、高血压、酗酒和吸烟有关。结论：透镜厚度与白内障发病率有关。解释这些关系的机制需要进一步的实验室和流行病学调查。
PURPOSE: To evaluate whether lens thickness is related to incidence of cataracts.METHODS: Lens thickness was measured from slit-lamp photographs of the lens at the time of the prevalence evaluation in the Beaver Dam Eye Study. Incident cataract was determined by grading standard slit-lamp and retroillumination photographs of the lens at the baseline and five-year follow-up examinations. Medical history was obtained and blood pressures, height and weight were measured according to protocol.RESULTS: Lens thickness was positively associated with incident nuclear cataract and inversely associated with incident cortical cataract after accounting for age, sex, diabetes status, hypertension, heavy drinking and cigarette smoking.CONCLUSIONS: Lens thickness is related to incidence of cataracts. Mechanisms to explain these relationships require further laboratory and epidemiologic investigation.