THE PREVALENCE OF CHLAMYDIA-TRACHOMATIS INFECTION AMONG MOTHERS OF CHILDREN WITH TRACHOMA
THE PREVALENCE OF CHLAMYDIA-TRACHOMATIS INFECTION AMONG MOTHERS OF CHILDREN WITH TRACHOMA
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DOI：
10.1093/oxfordjournals.aje.a115737
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发表时间：
1990-11-01
影响因子：
5
通讯作者：
PLUMMER, FA
中科院分区：
文献类型：
--
作者：
BRUNHAM, RC;LAGA, M;PLUMMER, FA
作者研究了肯尼亚中部（非洲）沙眼流行地区沙眼衣原体感染的流行病学。对异常眼分泌物的儿童进行了沙眼临床证据评估，并进行了C培养。沙眼分离的C.用单克隆抗体对沙眼进行免疫分型。共有来自207个家庭的221名儿童接受了评估。临床上，91名儿童（41%）有沙眼性滤泡炎，130名（59%）有乳头肥大，无可见滤泡，并标记为粘液脓性结膜炎。C. 91例沙眼患儿中31例（34%）分离出沙眼衣原体，130例结膜炎患儿中17例（13%）分离出沙眼衣原体（P < 0.001）。二十二度对沙眼菌株进行免疫分型：17个来自患有沙眼的儿童（9个A型，1个A/L2型，5个B型，1个Ba型和1个E型），5个来自患有结膜炎的儿童（2个A型，1个Ba型，1个D型和1个F型）。共有168名母亲进行了宫颈C。沙眼感染，7例（4%）培养阳性。免疫分型为E型。作者认为C.沙眼眼感染是由于异质性血清型在这个地区，大多数沙眼病例是由于C。沙眼衣原体感染与经典的沙眼血清型（A，B，或Ba），和宫颈C。沙眼感染在患有沙眼的儿童的母亲中并不常见。
The authors studied the epidemiology of Chlamydia trachomatis infection in a trachoma-endemic area of central Kenya (Africa). Children with abnormal ocular discharge were evaluated for clinical evidence of trachoma and were cultured for C. trachomatis. Isolated strains of C. trachomatis were immunotyped with monoclonal antibodies. Overall, 221 children from 207 families were evaluated. Clinically, 91 children (41%) had trachomatous follicular inflammation, and 130 (59%) had papillary hypertrophy without visible follicle and were labeled as having mucopurulent conjunctivitis. C. trachomatis was isolated from 31 of 91 children with trachoma (34%) and 17 of 130 children with conjunctivitis (13%) (p < 0.001). Twenty-two C. trachomatis strains were immunotyped: 17 were from children with trachoma (nine type A, one A/L2, five B, one Ba, and one E) and five were from children with conjunctivitis (two A, one Ba, one D, and one F). A total of 168 mothers were evaluated for cervical C. trachomatis infection, and seven (4%) were culture-positive. Two strains were immunotyped as serovar E. The authors conclude that C. trachomatis ocular infections are due to heterogeneous serovars in this area, that most cases of trachoma are due to C. trachomatis infection with the classic trachoma serovars (A, B, or Ba), and that cervical C. trachomatis infection is uncommon among mothers of children with trachoma.