Immuno-phenotyping of Canadian beef cattle: adaptation of the high immune response methodology for utilization in beef cattle.
Immuno-phenotyping of Canadian beef cattle: adaptation of the high immune response methodology for utilization in beef cattle.
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DOI：
10.1093/tas/txac006
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发表时间：
2022-01
影响因子：
1.3
通讯作者：
Mallard BA
中科院分区：
文献类型：
--
作者：
Husseini N;Beard SC;Hodgins DC;Barnes C;Chik E;Mallard BA
高免疫应答（HIR）方法测量适应性免疫系统的遗传性能，以识别和繁殖具有平衡和强大免疫力的动物。HIR方法以前曾用于奶牛和猪以减少疾病，但尚未在肉牛中进行充分研究。本研究的第一个目的是检查用于奶牛的标准化HIR方法是否适用于肉牛。第二个目的是确定肉牛免疫应答表型的最早年龄。在本研究中，使用测试抗原对不同年龄的肉牛（n = 295）以及混合品种的成熟肉牛（n = 170）进行免疫，以评估其抗体（AMIR）和细胞介导的免疫反应（CMIR）。AMIR和CMIR的遗传力估计分别为0.43和0.18。HIR方法适用于肉牛; 2 - 3周龄的肉牛能够产生AMIR反应，与成熟荷斯坦奶牛中的历史反应相当。3周龄肉牛的CMIR反应与荷斯坦奶牛相当，但9月龄犊牛和成熟肉牛的CMIR反应显著高于荷斯坦奶牛。HIR方法可用于测量3周龄肉牛的AMIR和CMIR。
The high immune response (HIR) methodology measures the genetic performance of the adaptive immune system to identify and breed animals with balanced and robust immunity. The HIR methodology has previously been used in dairy and swine to reduce disease but has not been fully investigated in beef cattle. The first objective of the current study was to examine whether the HIR methodology as standardized for use in dairy cattle was appropriate for use in beef cattle. The second objective was to determine the earliest age for immune response phenotyping of beef calves. In this study, beef calves (n = 295) of various ages, as well as mature beef cows (n = 170) of mixed breeds, were immunized using test antigens to assess their antibody- (AMIR) and cell-mediated immune responses (CMIR). Heritability for AMIR and CMIR was estimated at 0.43 and 0.18, respectively. The HIR methodology was appropriate for use in beef cattle; beef calves as young as 2–3 wk of age were capable of mounting AMIR responses comparable with those seen historically in mature Holstein dairy cows. Three-week-old beef calves mounted CMIR responses comparable with those of Holstein cows, but 9-mo-old calves and mature beef cows had significantly higher CMIR responses than Holsteins. The HIR methodology can be used to measure both AMIR and CMIR in beef calves as young as 3 wk of age.