Inflammasome as an Effective Platform for Fibrosis Therapy.
Inflammasome as an Effective Platform for Fibrosis Therapy.
复制标题
炎性体作为纤维化治疗的有效平台。
DOI：
10.2147/jir.s304180
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发表时间：
2021
影响因子：
4.5
通讯作者：
Sun WY
中科院分区：
文献类型：
--
作者：
Chen TT;Xiao F;Li N;Shan S;Qi M;Wang ZY;Zhang SN;Wei W;Sun WY
纤维化是慢性炎症发展的最后阶段。其特点是细胞外基质过度沉积，导致组织结构损伤和器官功能障碍，严重威胁人类健康和生命。然而，纤维化的分子机制仍不清楚。炎症体是一种蛋白质的分子复合体，已成为宿主免疫的关键先天感受器，参与了下垂、病原体感染、代谢综合征、细胞应激和肿瘤转移。炎症小体信号和炎症小体介导的下游细胞因子反应在纤维化中起重要作用。炎症小体调节IL-1β和IL-18的分泌，而IL-1和IL-18在纤维化过程中起关键作用。近年来，有关炎性小体功能的研究引起了人们的广泛关注，这些研究数据加深了我们对炎性小体在纤维化过程中的作用和调控的认识。在这篇综述中，我们强调了越来越多的证据表明炎性小体在触发纤维化中的间接和直接作用，以及潜在的抗纤维化治疗的新靶点。
Fibrosis is the final stage of the development of chronic inflammation. It is characterized by excessive deposition of the extracellular matrix, leading to tissue structure damage and organ dysfunction, which is a serious threat to human health and life. However, the molecular mechanism of fibrosis is still unclear. Inflammasome is a molecular complex of proteins that has been becoming a key innate sensor for host immunity and is involved in pyroptosis, pathogen infection, metabolic syndrome, cellular stress, and tumor metastasis. Inflammasome signaling and downstream cytokine responses mediated by the inflammasome have been found to play an important role in fibrosis. The inflammasome regulates the secretion of IL-1β and IL-18, which are both critical for the process of fibrosis. Recently, researches on the function of inflammasome have attracted extensive attention, and data derived from these researches have increased our understanding of the effects and regulation of inflammasome during fibrosis. In this review, we emphasize the growing evidence for both indirect and direct effects of inflammasomes in triggering fibrosis as well as potential novel targets for antifibrotic therapies.