Costimulation blockade inhibits the indirect pathway of allorecognition in nerve allograft rejection.
Costimulation blockade inhibits the indirect pathway of allorecognition in nerve allograft rejection.
复制标题
共刺激阻断抑制神经同种异体移植排斥中同种异体识别的间接途径。
DOI：
10.1002/mus.21807
复制
发表时间：
2011
期刊：
影响因子：
3.4
通讯作者：
Tung,ThomasH
中科院分区：
文献类型：
--
作者：
Ray,WilsonZ;Kasukurthi,Rahul;Kale,SantoshS;Santosa,KatherineB;Hunter,DanielA;Johnson,Philip;Yan,Ying;Mohanakumar,Thalachallour;Mackinnon,SusanE;Tung,ThomasH
同种异体神经移植为宿主神经再生提供了一个临时的支架。对全身免疫抑制的需要限制了临床应用。诱导免疫低反应性的免疫机制的表征可以为优化免疫调节方案提供基础。我们利用野生型和MHC II类缺陷小鼠作为受体和供体。宿主处理由三重共刺激阻断组成。在3周时使用神经组织形态计量学进行定量评估，并在7周时对动物子集进行肌肉测试。只要直接或间接通路功能正常，就会发生神经移植排斥反应。间接抗原呈递似乎更重要。神经同种异体移植排斥反应发生在没有正常的直接或间接免疫反应，但可能更依赖于间接同种异体识别。间接途径是诱导共刺激阻断免疫低反应所必需的。肌肉神经，2011年
Nerve allografts provide a temporary scaffold for host nerve regeneration. The need for systemic immunosuppression limits clinical application. Characterization of the immunological mechanisms that induce immune hyporesponsiveness may provide a basis for optimizing immunomodulating regimens. We utilized wild‐type and MHC class II–deficient mice, as both recipients and donors. Host treatment consisted of triple costimulatory blockade. Quantitative assessment was made at 3 weeks using nerve histomorphometry, and muscle testing was performed on a subset of animals at 7 weeks. Nerve allograft rejection occurred as long as either the direct or indirect pathways were functional. Indirect antigen presentation appeared to be more important. Nerve allograft rejection occurs in the absence of a normal direct or indirect immune response but may be more dependent on indirect allorecognition. The indirect pathway is required to induce costimulatory blockade immune hyporesponsiveness. Muscle Nerve, 2011