Abnormal regional spontaneous neural activity in first-episode, treatment-naive patients with late-life depression: A resting-state fMRI study
Abnormal regional spontaneous neural activity in first-episode, treatment-naive patients with late-life depression: A resting-state fMRI study
复制标题
初治晚年抑郁症患者的异常局部自发神经活动：一项静息态功能磁共振成像研究
DOI：
10.1016/j.pnpbp.2012.07.004
复制
发表时间：
2012-12-03
影响因子：
5.6
通讯作者：
Chen, Huafu
中科院分区：
文献类型：
--
作者：
Liu, Feng;Hu, Maorong;Chen, Huafu
背景资料：先前的静息灌注或基于任务的研究提供了晚年抑郁症（LLD）患者大脑功能变化的证据。到目前为止，人们对LLD在静息状态下自发脑活动的变化知之甚少。本研究的目的是通过静息态功能磁共振成像（fMRI）研究首发、未经治疗的LID患者的自发神经活动。一种新的分析方法，基于相干性的区域均匀性（Cohe-ReHo），用于评估15例首次发作患者静息状态下的局部自发神经活动，LID患者和15名年龄和性别匹配的健康对照。与健康对照组相比，LLD组左侧尾状核、右侧扣带回前部、左侧背外侧前额叶皮层、右侧角回、双侧内侧前额叶皮层、左侧小脑后叶、左侧上级颞回、双侧辅助运动区和右侧中央后回的Cohe-ReHo显著增加（p
Background: The previous resting perfusion or task-based studies have provided evidence of functional changes in the brains of patients with late-life depression (LLD). Little is known, so far, about the changes in the spontaneous brain activity in LLD during the resting state. The aim of this study was to investigate the spontaneous neural activity in first-episode, treatment-naive patients with LID by using resting-state functional magnetic resonance imaging (fMRI).Methods: A novel analytical method, coherence-based regional homogeneity (Cohe-ReHo), was used to assess regional spontaneous neural activity during the resting state in 15 first-episode, treatment-naive patients with LID and 15 age- and gender-matched healthy controls.Results: Compared to the healthy controls, the LLD group showed significantly decreased Cohe-ReHo in left caudate nucleus, right anterior cingulate gyrus, left dorsolateral prefrontal cortex, right angular gyrus, bilateral medial prefrontal cortex, and right prec-uneus, while significantly increased Cohe-ReHo in left cerebellum posterior lobe, left superior temporal gyrus, bilateral supplementary motor area, and right postcentral gyrus (p