Polyunsaturated fatty acids and the risk of multiple sclerosis.
Polyunsaturated fatty acids and the risk of multiple sclerosis.
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DOI：
10.1177/1352458517691150
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发表时间：
2017-12
期刊：
影响因子：
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通讯作者：
Munger KL
中科院分区：
文献类型：
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作者：
Bjørnevik K;Chitnis T;Ascherio A;Munger KL
先前关于多不饱和脂肪酸摄入量和多发性硬化症(MS)风险的研究结果相互矛盾。前瞻性研究膳食中多不饱和脂肪酸摄入量与多发性硬化症风险之间的关系。我们跟踪了护士健康研究(1984-2004)的80,920名女性和护士健康研究II(1991-2009)的94,511名女性，她们每4年使用有效的食物频率问卷报告饮食，在随访期间确定了479例多发性硬化症病例。我们使用COX回归估计风险比(HR)和95%可信区间(CI)，根据年龄、15岁居住的纬度、血统、吸烟、补充维生素D摄入量、体重指数和总能量摄入量调整多不饱和脂肪酸摄入量对MS风险的影响。基线时摄入总多不饱和脂肪酸与较低的MS风险相关(HR上下五分之一：0.67，95%CI：0.49-0.90，p趋势=0.01)。在特定类型的多不饱和脂肪酸中，只有α-亚麻酸(ALA)与MS风险呈负相关(HR上下五分位数：0.61，95%CI：0.45~0.83，p趋势=0.001)。长链脂肪酸二十碳五烯酸(EPA)和二十二碳六烯酸(DHA)与MS风险无关。饮食中多不饱和脂肪酸摄入量低可能是MS的另一个可修改的危险因素。
Results from previous studies on PUFA intake and multiple sclerosis (MS) risk are conflicting. To prospectively investigate the association between dietary intake of PUFA and MS risk. We followed 80,920 women from Nurses' Health Study (1984–2004) and 94,511 women from Nurses' Health Study II (1991–2009) who reported on diet using a validated food frequency questionnaire every 4 years, and identified 479 incident MS cases during follow-up. We used Cox regression to estimate hazard ratios (HR) and 95% confidence intervals (CI), for the effect of PUFA intake on MS risk adjusting for age, latitude of residence at age 15, ancestry, cigarette smoking, supplemental vitamin D intake, body mass index, and total energy intake. Higher intake of total PUFA at baseline was associated with a lower risk of MS (HR top vs. bottom quintile: 0.67, 95% CI: 0.49–0.90, p trend=0.01). Among the specific types of PUFA, only α-linolenic acid (ALA) was inversely associated with MS risk (HR top vs. bottom quintile: 0.61, 95% CI: 0.45–0.83, p trend=0.001). The long-chain fatty acids eicosapentaenoic acid (EPA) and docosahexaenoic acid (DHA) were not associated with MS risk. Low dietary PUFA intake may be another modifiable risk factor for MS.