Stromal PDGFRbeta expression in prostate tumors and non-malignant prostate tissue predicts prostate cancer survival.
Stromal PDGFRbeta expression in prostate tumors and non-malignant prostate tissue predicts prostate cancer survival.
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DOI：
10.1371/journal.pone.0010747
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发表时间：
2010-05-20
期刊：
影响因子：
3.7
通讯作者：
Ostman A
中科院分区：
文献类型：
--
作者：
Hägglöf C;Hammarsten P;Josefsson A;Stattin P;Paulsson J;Bergh A;Ostman A
新的前列腺癌预后标志物的鉴定是非常必要的，因为很难确定需要治愈性治疗的患者。来自实验模型和临床样本的数据已经确定了PDGFRβ对肿瘤间质中的周细胞和成纤维细胞的重要功能。在这项研究中，PDGFRβ在前列腺癌间质和匹配的非恶性组织中的预后意义通过免疫组织化学进行了评估。分析了300多例前列腺癌患者正常和肿瘤间质中PDGFRβ的表达。肿瘤间质中PDGFRβ高表达与肿瘤体积大、分期晚、Gleason评分高和血管密度高有关。肿瘤血管周围PDGFRβ染色也与高Gleason评分相关。肿瘤间质和非恶性间质中PDGFRβ状态之间也观察到相关性。类似地，邻近非恶性组织间质中的高PDGFRβ表达与大肿瘤大小、晚期、高Gleason评分和非恶性上皮细胞增殖相关。有趣的是，肿瘤间质和非恶性组织中高水平的PDGFRβ与前列腺癌患者较短的癌症特异性生存期相关。该研究揭示了前列腺肿瘤中基质PDGFRβ表达与几个重要临床特征（包括生存率）之间的一些新关联。
The identification of new prognostic markers for prostate cancer is highly warranted, since it is difficult to identify patients requiring curative treatment. Data from both experimental models and clinical samples have identified important functions of PDGFRβ on pericytes and fibroblasts in the tumor stroma. In this study the prognostic significance of PDGFRβ in prostate cancer stroma, and in matched non-malignant tissue, was evaluated with immunohistochemistry. PDGFRβ expression was analyzed in normal and tumor stroma from more than 300 prostate cancer patients. High PDGFRβ expression in tumor stroma was associated with large tumor size, advanced stage, high Gleason score and high vessel density. Perivascular PDGFRβ staining in tumors was also correlated with high Gleason score. Correlations were also observed between PDGFRβ status in tumor stroma and non-malignant stroma. Similarly, high PDGFRβ expression in adjacent non-malignant tissue stroma correlated with large tumor size, advanced stage, high Gleason score and proliferation in non-malignant epithelium. Interestingly, high levels of PDGFRβ in the stroma of tumor and non-malignant tissue were associated with shorter cancer specific survival in prostate cancer patients. The study revealed a number of novel associations between stromal PDGFRβ expression in prostate tumors and several important clinical characteristics, including survival.
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DOI：
10.1073/pnas.90.2.393
发表时间：
1993-01-15
影响因子：
11.1
作者：
FORSBERG, K;VALYINAGY, I;WESTERMARK, B
通讯作者：
WESTERMARK, B
影响因子：
11.5
作者：
Mathew, Paul;Thall, Peter F.;Logothetis, ChristopherJ.
通讯作者：
Logothetis, ChristopherJ.
影响因子：
6
作者：
Kitadai, Yasuhiko;Sasaki, Takamitsu;Fidler, Isaiah J.
通讯作者：
Fidler, Isaiah J.
影响因子：
7.5
作者：
Nupponen, Nina N.;Paulsson, Janna;Hasselblatt, Martin
通讯作者：
Hasselblatt, Martin
影响因子：
2.8
作者：
Johansson, Anna;Jones, Jonathan;Bergh, Anders
通讯作者：
Bergh, Anders