Bone Marrow Adipocytes: A Link between Obesity and Bone Cancer.
Bone Marrow Adipocytes: A Link between Obesity and Bone Cancer.
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骨髓脂肪细胞：肥胖与骨癌之间的联系。
DOI：
10.3390/cancers13030364
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发表时间：
2021-01-20
期刊：
影响因子：
5.2
通讯作者：
Rosen CJ
中科院分区：
文献类型：
--
作者：
Reagan MR;Fairfield H;Rosen CJ
这篇综述讨论了骨髓脂肪组织在癌症进展中新确立的重要作用，并重点介绍了该研究，该研究证明了临床靶向肿瘤细胞的巨大前景。骨髓脂肪组织在衰老和肥胖过程中会扩张。它主要包含骨髓脂肪细胞（也称为脂肪细胞），还可以包含其他细胞，例如前脂肪细胞、成纤维细胞、巨噬细胞、其他免疫细胞和内皮细胞。骨髓脂肪细胞分散在整个造血或“红”骨髓中，或者密集地堆积在骨髓腔中，形成“黄”骨髓。骨髓生物学家正在研究许多问题，以了解骨髓脂肪细胞的性质，包括衰老和肥胖如何影响这些细胞；它们的起源、功能和内分泌作用；以及它们是否可以靶向治疗骨质疏松症。与此同时，癌症研究人员正在描述骨髓脂肪细胞在肿瘤学中的作用及其对未来治疗的潜在转化意义。对于大多数患者来说，在骨髓中生长的癌症是可怕的、痛苦的且无法治愈的。由于它们所在的骨髓生态位提供了支持性微环境，这些癌症特别难以治疗。针对肿瘤细胞的新疗法延长了这些患者的预期寿命，但需要更好的疗法，并且如何针对这些癌症的新想法至关重要。这种需求促使研究人员质疑骨髓脂肪细胞（BMAd）在衰老和肥胖过程中数量和大小的增加是否会导致骨髓内癌症的发生或进展。在全球范围内，该领域的共识是统一的“是”。然而，如何靶向这些脂肪细胞或它们产生的因子以及 BMAd 如何与不同肿瘤细胞相互作用是悬而未决的研究问题。在此，我们回顾这一研究领域，目标是加速该领域实验室网络的研究，并吸引具有新观点和想法的杰出科学家进入该领域，以便为骨癌患者带来更好的治疗。
This review discusses the important newly-established roles for bone marrow adipose tissue in cancer progression and highlights the research demonstrating great promise for clinically targeting the cells in oncology. Bone marrow adipose tissue expands during aging and in obesity. It primarily comprises bone marrow adipocytes (also known as fat cells) and can also contain other cells, such as pre-adipocytes, fibroblasts, macrophages, other immune cells, and endothelial cells. Bone marrow adipocytes are scattered throughout the hematopoietic or “red” marrow, or are densely packed in the marrow cavity, creating “yellow” marrow. Bone marrow biologists are interrogating many questions to understand the nature of bone marrow adipocytes, including how aging and obesity affect these cells; their origins, functions, and endocrine roles; and whether they can be targeted to treat osteoporosis. In parallel, and often in concert, cancer researchers are delineating the role of bone marrow adipocytes in oncology and their potential translational significance for future therapeutics. Cancers that grow in the bone marrow are for most patients scary, painful, and incurable. These cancers are especially hard to treat due to the supportive microenvironment provided by the bone marrow niche in which they reside. New therapies designed to target tumor cells have extended the life expectancy for these patients, but better therapies are needed and new ideas for how to target these cancers are crucial. This need has led researchers to interrogate whether bone marrow adipocytes (BMAds), which increase in number and size during aging and in obesity, contribute to cancer initiation or progression within the bone marrow. Across the globe, the consensus in the field is a unified “yes”. However, how to target these adipocytes or the factors they produce and how BMAds interact with different tumor cells are open research questions. Herein, we review this research field, with the goal of accelerating research in the network of laboratories working in this area and attracting bright scientists with new perspectives and ideas to the field in order to bring about better therapies for patients with bone cancers.
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骨髓脂肪形成增加不会导致雌性小鼠年龄依赖性的阑尾骨质流失。
影响因子：
7.8
作者：
Almeida M;Kim HN;Han L;Zhou D;Thostenson J;Porter RM;Ambrogini E;Manolagas SC;Jilka RL
通讯作者：
Jilka RL
影响因子：
4.1
作者：
Fairfield H;Falank C;Farrell M;Vary C;Boucher JM;Driscoll H;Liaw L;Rosen CJ;Reagan MR
通讯作者：
Reagan MR
影响因子：
6
作者：
Clark, Robert;Krishnan, Venkatesh;Rinker-Schaeffert, Carrie
通讯作者：
Rinker-Schaeffert, Carrie
影响因子：
--
作者：
Diedrich JD;Rajagurubandara E;Herroon MK;Mahapatra G;Hüttemann M;Podgorski I
通讯作者：
Podgorski I
DOI：
10.1002/jbmr.4170
发表时间：
2021-01
期刊：
Journal of bone and mineral research : the official journal of the American Society for Bone and Mineral Research
影响因子：
--
作者：
Farrell M;Fairfield H;Costa S;D'Amico A;Falank C;Brooks DJ;Reagan MR
通讯作者：
Reagan MR