Association of Hypertension and Breast Cancer: Antihypertensive Drugs as an Effective Adjunctive in Breast Cancer Therapy.
Association of Hypertension and Breast Cancer: Antihypertensive Drugs as an Effective Adjunctive in Breast Cancer Therapy.
复制标题
高血压与乳腺癌的关联：抗高血压药物作为乳腺癌治疗的有效辅助药物
DOI：
10.2147/cmar.s350854
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发表时间：
2022
影响因子：
3.3
通讯作者：
Jiang E
中科院分区：
文献类型：
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作者：
Fan Y;Khan NH;Farhan Ali Khan M;Ahammad MDF;Zulfiqar T;Virk R;Jiang E
摘要乳腺癌是女性最常见的恶性肿瘤，其在年轻女性中的发病率在世界范围内呈上升趋势。BC的早发是一个多步骤的过程，涉及各种生物侵袭性肿瘤，如三阴性和人表皮生长因子2（HER 2）阳性癌症。在地球仪范围内，预防BC仍然是一项艰巨的任务。一系列的观察性研究已经确定了高血压（HTN）和侵袭性BC发展之间的结论性非遗传临床联系。这些临床关联促使药理学寻求使用抗高血压（AHTN）药物作为BC治疗中的有效药物。使用AHTN，特别是β-受体阻滞剂和噻嗪类药物，已被公认为是一种有效的抗肿瘤药物，可缓解BC进展，减少癌症治疗的副作用，并阻止幸存者的癌症复发。考虑到迫切需要传播关于如何选择AHTN药物作为治疗BC的有效治疗方法的研究，本综述旨在提供关于AHTN药物作为额外的癌症治疗对BC的关联和机制的新认识。
Abstract Breast cancer (BC) is the most common malignancy affecting women, and its incidence in younger women is rising worldwide. Early-onset of BC is a multi-step process involving various biological aggressive tumors such as triple negative and human epidermal growth factor 2 (HER2)-positive cancers. BC prevention is still arduous across the globe. A series of observational studies have established a conclusive non-genetic clinical link between hypertension (HTN) and the development of invasive BC. Those clinical associations have driven a pharmacological seek to use the anti-hypertension (AHTN) drugs as an effective adjunctive in BC therapy. The use of AHTN, especially beta-blockers and thiazides, has been recognized as a potent anti-tumor drug to mitigate BC progression, reduce the side effects of cancer treatment, and stop the reoccurrence of cancer in the survivors. Considering the dire need to disseminate the research on how AHTN drugs can be opted as the effective adjunctive therapy to cure the BC, the current review aimed to provide an update on novel understandings on association and mechanisms of AHTN-drugs against BC as an additional cancer therapy.
DOI：
10.1007/s11325-020-02047-8
发表时间：
2021-03
期刊：
Sleep & breathing = Schlaf & Atmung
影响因子：
--
作者：
Leppänen T;Kulkas A;Töyräs J;Myllymaa S;Gadoth N;Oksenberg A
通讯作者：
Oksenberg A