Motion correction to enhance absolute myocardial blood flow quantitation by PET.
Motion correction to enhance absolute myocardial blood flow quantitation by PET.
复制标题
运动校正可增强 PET 的绝对心肌血流量定量。
DOI：
10.1007/s12350-019-01912-8
复制
发表时间：
2020
期刊：
影响因子：
--
通讯作者：
Packard,RenéRSevag
中科院分区：
文献类型：
--
作者：
Votaw,JohnR;Packard,RenéRSevag
在本期《核心脏病学杂志》中，Poitrasson-Riviere 等人提出，在评估正电子发射断层扫描 (PET) 得出的绝对心肌血流量 (MBF) 和心肌血流储备 (MFR) 时，先进行自动运动校正，然后由技术人员手动调整，可减少用户间的变异性。 1 我们将强调 PET MFR 评估的重要性，概述与运动相关的问题和建议的修正，讨论文章的基本特征，并提出未来的方向。已证明患有或不患有心外膜冠状动脉疾病 (CAD) 的患者的冠状血管舒张功能具有显着的增量和独立的预后意义，2 将* 1/3 的中危患者正确重新分类为低风险和高风险心血管死亡组。 3 在关键的亚组分析中也发现了类似的预后显着改善。例如，在没有明显心外膜 CAD 的糖尿病患者中，MFR 受损与死亡率相关，与既往患有 CAD 的患者相当。 4 相反，MFR 保持不变的糖尿病患者的事件发生率与非糖尿病患者相当。 4 类似的观察
In this issue of the Journal of Nuclear Cardiology, Poitrasson-Riviere et al propose that automated motion correction followed by technologist manual adjustment reduces inter-user variability in the assessment of positron-emission tomography (PET)-derived absolute myocardial blood flow (MBF) and myocardial flow reserve (MFR). 1 We will highlight the importance of PET MFR assessment, provide an overview of issues related to motion and suggested corrections, discuss essential features of the article, and propose future directions.Coronary vasodilator function in patients with or without epicardial coronary artery disease (CAD) has been demonstrated to carry significant incremental and independent prognostic significance, 2 with correct reclassification of* 1/3 of intermediate-risk patients into low-and high-risk cardiovascular mortality groups. 3 A similar strong improvement in prognosis has been determined in key subgroup analyses. For example, among diabetic patients without significant epicardial CAD, impaired MFR was associated with mortality rates comparable to those with prior CAD. 4 Conversely, diabetics with preserved MFR have event rates comparable to those of nondiabetics. 4 Similar observations