Relative Proportions of Stromal to Cellular Components of Pleomorphic Adenomas Determination With Shear Wave Elastography
Relative Proportions of Stromal to Cellular Components of Pleomorphic Adenomas Determination With Shear Wave Elastography
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DOI：
10.7863/ultra.33.3.503
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发表时间：
2014-03-01
影响因子：
2.3
通讯作者：
Mihmanli, Ismail
中科院分区：
文献类型：
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作者：
Olgun, Deniz Cebi;Kantarci, Fatih;Mihmanli, Ismail
Objectives-本研究的目的是评估多形性腺瘤的间质细胞成分的相对比例是否对剪切弹性模量有影响，剪切弹性模量由剪切波elastography（SWE）.Methods确定，本研究由本机构的伦理委员会批准，并于2011年9月至2012年12月进行。35例腮腺肿块手术患者纳入研究。通过SWE测量质量的最大剪切弹性模量。结果多形性腺瘤的最大剪切弹性模量值为12.6 ~ 291.9 kPa（mean +/- SD，120.9 +/- 92.8 kPa）。Friedman检验揭示了基质量和最大剪切弹性模量之间的统计学显著关系（P < .001）。SWE显示间质贫乏腺瘤（平均值，32.3 ± 27.7 kPa;范围，12.6-81.1 kPa）比间质丰富腺瘤（平均值，174.1 ± 48.4 kPa;范围，92.7-217.2 kPa; P = 0.009）软。在间质贫乏型和中间型间质型肿瘤之间没有检测到这种显著差异（平均值：146.3 ± 106.1 kPa;范围：19.1-291.9 kPa; P = 0.062）或中间间质肿瘤与富含间质肿瘤之间结论剪切波弹性成像显示多形性腺瘤具有不同的外观，这是由于肿瘤中基质与细胞内容物的相对比例。
Objectives-The purpose of this study was to evaluate whether the relative proportions of stromal to cellular components of pleomorphic adenomas have an effect on the shear elastic modulus determined by shear wave elastography (SWE).Methods This study was approved by the Ethics Committee of our institution and performed between September 2011 and December 2012. Thirty-five patients who underwent surgery for a parotid mass were included in the study. The maximum shear elastic modulus of the mass was measured by SWE. Pleomorphic adenomas were histopathologically subdivided into stroma-poor, intermediate-stroma, and stroma-rich tumors based on the relative proportion of stromal to cellular components.Results The maximum shear elastic modulus values of the pleomorphic adenomas ranged from 12.6 to 291.9 kPa (mean +/- SD, 120.9 +/- 92.8 kPa). The Friedman test revealed a statistically significant relationship between the stromal amount and maximum shear elastic modulus (P < .001). Stroma-poor adenomas (mean, 32.3 +/- 27.7 kPa; range, 12.6-81.1 kPa) were softer on SWE than stroma-rich adenomas (mean, 174.1 +/- 48.4 kPa; range, 92.7-217.2 kPa; P = .009). No such significant difference was detected between stroma-poor and intermediate-stroma tumors (mean, 146.3 +/- 106.1 kPa; range, 19.1-291.9 kPa; P = .062) or between intermediate-stroma and stroma-rich tumors (P = .465).Conclusions Shear wave elastography depicts pleomorphic adenomas with a variable appearance, which is due to the relative proportions of stromal to cellular contents in the tumors.