Decreased autologous mixed lymphocyte reaction in Sjögren's syndrome.
Decreased autologous mixed lymphocyte reaction in Sjögren's syndrome.
复制标题
干燥综合征中自体混合淋巴细胞反应减少。
DOI：
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复制
发表时间：
1980
影响因子：
15.9
通讯作者：
N. Talal
中科院分区：
文献类型：
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作者：
N. Miyasaka;B. Sauvezie;D. Pierce;T. Daniels;N. Talal
自体混合淋巴细胞反应（AMLR）测量外周血T细胞对存在于非T细胞表面上的抗原的反应。对25名干燥综合征（SS）患者进行了AMLR研究。25例SS患者中有15例（60%）AMLR降低（5，272 +/-6，738 cpm vs.正常对照组14，396 +/-10，092 cpm，P < 0.001）。15名仅患有腺体疾病且未服用任何全身药物的患者中，有8名的AMLR下降。与SS和相关疾病的患者有较低的反应比SS单独的患者。2例假性淋巴瘤患者无反应。AMLR的降低与伴刀豆球蛋白A反应的降低相关，提示T细胞亚群可能异常。AMLR降低与年龄、病灶评分、血清免疫球蛋白浓度、抗淋巴细胞抗体滴度、植物血凝素反应无相关性。在同种异体MLR中，SS非T细胞和巨噬细胞刺激正常同种异体T细胞不如正常非T细胞和巨噬细胞，这表明在同种异体MLR中刺激的细胞中刺激的细胞可能异常。
The autologous mixed lymphocyte reaction (AMLR) measures the response of peripheral blood T cells to antigens present on the surface of non-T cells. The AMLR was studied in 25 patients with Sjögren's syndrome (SS). The AMLR was decreased in 15 of 25 (60%) of patients with SS (5,272 +/- 6,738 cpm vs. 14,396 +/- 10,092 cpm for the normal controls, P < 0.001). The AMLR was decreased in 8 of 15 patients with only glandular disease who were not on any systemic medications. Patients with SS and associated disease had lower responses than patients with SS alone. Two patients with pseudolymphoma had absent response. The decreased AMLR correlated with a decreased response to concanavalin A, suggesting a possible abnormality of a T cell subpopulation. There was no correlation between the decreased AMLR and age, focus score, serum immunoglobulin concentration, the titer of antilymphocyte antibody, or phytohemagglutinin response. In allogeneic MLR, SS non-T cells and macrophages stimulated normal allogeneic T cells less well than normal non-T cells and macrophages, suggesting a possible abnormality in the cells that stimulate in the cells that stimulate in the allogeneic MLR.