Gonadotropin-suppressive therapy in girls with early and fast puberty affects the pace of puberty but not total pubertal growth or final height
Gonadotropin-suppressive therapy in girls with early and fast puberty affects the pace of puberty but not total pubertal growth or final height
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DOI：
10.1210/jc.87.5.2090
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发表时间：
2002-05-01
影响因子：
5.8
通讯作者：
Phillip, M
中科院分区：
文献类型：
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作者：
Lazar, L;Kauli, R;Phillip, M
女孩青春期提前和快速（EFP），定义为青春期开始于8-9岁，具有加速的过程，可能会导致最终身高（FHt）受损和心理社会困扰。用促性腺激素抑制剂治疗是有争议的，因为FHt的改善是不确定的，可能有肥胖的风险。我们分析了126名EFP女孩的数据：63名从坦纳3期开始接受GnRH类似物（GnRHA）治疗2-4年; 63名未经治疗。青春期开始的年龄;从坦纳2期到3期的加速过渡时间（
Early and fast puberty (EFP) in girls, defined as pubertal onset at age 8-9 yr, with an accelerated course, may cause compromised final height (FHt) and psychosocial distress. Treatment with a gonadotropin-suppressive agent is controversial, because the improvement in FHt is equivocal and there may be risk of obesity.We analyzed the data of 126 girls with EFP: 63 treated with GnRH analog (GnRHA) since Tanner stage 3, for 2-4 yr; and 63 untreated. Age at onset of puberty; accelerated time of transition from Tanner stage 2 to 3 (