Factors influencing survival in pediatric acute leukemia. The SWCCSG experience, 1958–1970
Factors influencing survival in pediatric acute leukemia. The SWCCSG experience, 1958–1970
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影响儿童急性白血病生存的因素。SWCCSG 经验，1958-1970 年。
作者：
S. George;D. Fernbach;T. Vietti;M. Sullivan;D. Lane;M. E. Haggard;D. Berry;D. Lonsdale;D. Komp
从1958年到1970年，西南癌症化疗研究小组对新诊断的急性白血病病例进行了7项临床研究，共纳入了1024名患者。对这些病例进行了审查，以确定除治疗外影响生存的重要因素。在生存预后方面，最重要的变量是诊断时的年龄、白血病的组织学类型和初始外周血白细胞计数。这些变量的影响似乎在诊断后至少持续5年。基于这些变量，采用一种简单的启发式方法来定义患者的预后组。患者的种族、初始血小板计数、出血状况、肝、脾和淋巴结肿大状况具有额外的预后价值，但患者的性别、初始血红蛋白值或骨髓中原始细胞百分比似乎没有预后意义。
From 1958 through 1970 a total of 1,024 patients was entered on the 7 clinical studies of the Southwest Cancer Chemotherapy Study Group for newly diagnosed cases of acute leukemia. A review of these cases was undertaken to determine the important factors, other than therapy, influencing survival. The most important variables in terms of survival prognosis were found to be age at diagnosis, histologic type of leukemia, and initial peripheral blood leukocyte count. The influence of these variables appeared to persist for at least 5 years following diagnosis. Based on these variables, a simple heuristic approach was taken to define prognostic groups of patients. The patient's race, initial platelet count, hemorrhagic status, and enlargement status of liver, spleen, and nodes were of additional prognostic value, but there appeared to be no prognostic significance in the patient's sex, initial hemoglobin value, or percent of blast cells in the bone marrow.