The role of TNF-alpha and its receptors in the production of NGF and GDNF by astrocytes
The role of TNF-alpha and its receptors in the production of NGF and GDNF by astrocytes
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DOI：
10.1016/j.brainres.2006.07.120
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发表时间：
2006-10-20
期刊：
影响因子：
2.9
通讯作者：
Suzumura, Akio
中科院分区：
文献类型：
--
作者：
Kuno, Reiko;Yoshida, Yusuke;Suzumura, Akio
神经营养因子，神经生长因子（NGF）和胶质细胞系衍生的神经营养因子（GDNF），由星形胶质细胞产生，并且由包括细菌脂多糖和促炎细胞因子的炎性刺激诱导。在这项研究中，我们研究了肿瘤坏死因子-α（TNF-α）诱导的神经营养因子产生的调节机制。我们发现培养的星形胶质细胞同时表达TNF-α受体1（TNFR 1）和TNFR 2，TNF-α激活这些受体可促进NGF和GDNF的表达。此外，我们观察到不仅外源性TNF-α，而且星形胶质细胞产生的TNF-α诱导星形胶质细胞产生NGF和GDNF。这些结果表明，涉及TNF-α的自分泌回路有助于炎症反应中神经营养因子的产生。(c)2006 Elsevier B. V.保留所有权利。
The neurotrophic factors, nerve growth factor (NGF) and glial cell line-derived neurotrophic factor (GDNF), are produced by astrocytes, and are induced by inflammatory stimuli including bacterial lipopolysaccharide and pro-inflammatory cytokines. In this study, we examined the regulatory mechanisms of tumor necrosis factor-alpha (TNF-alpha)-induced production of neurotrophic factors. We show here that cultured astrocytes express both TNF-alpha receptor 1 (TNFR1) and TNFR2, and that activation of these receptors by TNF-alpha promotes expression of both NGF and GDNF. In addition, we observe that not only exogenous TNF-alpha but also TNF-alpha produced by astrocytes induce NGF and GDNF production in astrocytes. These results suggest that an autocrine loop involving TNF-alpha contributes to the production of neurotrophic factors in response to inflammation. (c) 2006 Elsevier B.V. All rights reserved.