Neuropsychological laterality indices of schizophrenia: interactions with gender.
Neuropsychological laterality indices of schizophrenia: interactions with gender.
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DOI：
10.1093/oxfordjournals.schbul.a033369
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发表时间：
1999
影响因子：
6.6
通讯作者：
J. Ragland;R. Gur;B. Klimas;N. Mcgrady;R. Gur
中科院分区：
文献类型：
--
作者：
J. Ragland;R. Gur;B. Klimas;N. Mcgrady;R. Gur
对75例精神分裂症患者(男性45例，女性30例)和75例人口学特征相匹配的健康对照组的神经行为偏侧性指数进行了检测，包括运动、感觉、语言和空间记忆以及语言和空间记忆领域。患者在不同的任务中都受到了损害，而且偏侧结果因领域而异。在运动、感觉或记忆任务中，没有证据表明可以通过大脑半球的相互作用来进行诊断。然而，患者在语言方面的损害比在空间领域更严重，这表明相对更大的左半球功能障碍。这一发现受到参与者性别的影响。虽然患者作为一个群体表现出比空间障碍更大的语言障碍，但男性患者在空间方面表现出预期的相对于语言表现的优势，而女性患者在这两个方面的表现都是相同的。这些结果强调了考察侧方效应的性别差异的重要性。这些发现还表明，尽管精神分裂症的左半球模型可能部分得到了更高认知功能的数据的支持，但这种支持并不延伸到更基本的运动和感觉领域。
Neurobehavioral laterality indices were examined across motor, sensory, language versus spatial, and verbal memory versus spatial memory domains for 75 patients with schizophrenia (45 men, 30 women) and 75 demographically matched healthy controls. Patients were impaired across tasks, and laterality results varied by domain. There was no evidence for diagnosis by hemisphere interactions in motor, sensory, or memory tasks. However, patients were more impaired in language than in spatial domains, which suggests relatively greater left hemisphere dysfunction. This finding was mediated by the sex of the participant. While patients as a group showed greater language than spatial impairment, male patients showed expected superiority in spatial relative to language performance, whereas female patients performed the same on both functions. These results underscore the importance of examining sex differences in laterality effects. The findings also demonstrate that, although the left hemisphere model of schizophrenia may be partially supported by data on higher cognitive functions, this support does not extend to more basic motor and sensory domains.