Potential Molecular Biomarkers of Vestibular Schwannoma Growth: Progress and Prospects.
Potential Molecular Biomarkers of Vestibular Schwannoma Growth: Progress and Prospects.
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DOI：
10.3389/fonc.2021.731441
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发表时间：
2021
影响因子：
4.7
通讯作者：
Wang B
中科院分区：
文献类型：
--
作者：
Zhang Y;Long J;Ren J;Huang X;Zhong P;Wang B
前庭神经鞘瘤（VS，也称为听神经瘤）是一种相对罕见的良性脑肿瘤，起源于第八脑神经的许旺细胞。肿瘤生长是神经外科医生决定是否选择积极治疗方法或定期磁共振成像（MRI）仔细随访的最重要因素，因为手术和放射会造成严重创伤并影响神经功能，而长期随访期间肿瘤扩大会压迫邻近神经和组织，导致进行性听力损失，耳鸣和眩晕。近年来，随着VS生物学研究的不断深入，一些调控merlin构象变化的蛋白质、炎性细胞因子、miRNAs、组织蛋白和脑脊液（CSF）成分被提出与肿瘤体积增大密切相关。本文综述了与VS生长相关的生物标志物的研究进展，为探索VS的生长过程和确定最佳治疗策略提供参考。
Vestibular schwannomas (VSs, also known as acoustic neuromas) are relatively rare benign brain tumors stem from the Schwann cells of the eighth cranial nerve. Tumor growth is the paramount factor for neurosurgeons to decide whether to choose aggressive treatment approach or careful follow-up with regular magnetic resonance imaging (MRI), as surgery and radiation can introduce significant trauma and affect neurological function, while tumor enlargement during long-term follow-up will compress the adjacent nerves and tissues, causing progressive hearing loss, tinnitus and vertigo. Recently, with the deepening research of VS biology, some proteins that regulate merlin conformation changes, inflammatory cytokines, miRNAs, tissue proteins and cerebrospinal fluid (CSF) components have been proposed to be closely related to tumor volume increase. In this review, we discuss advances in the study of biomarkers that associated with VS growth, providing a reference for exploring the growth course of VS and determining the optimal treatment strategy for each patient.
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