LipidomeDB Data Calculation Environment Has Been Updated to Process Direct-Infusion Multiple Reaction Monitoring Data
LipidomeDB Data Calculation Environment Has Been Updated to Process Direct-Infusion Multiple Reaction Monitoring Data
复制标题
LipidomeDB 数据计算环境已更新，可处理直接输注多重反应监测数据
作者：
Fruehan, Carl;Johnson, David;Welti, Ruth
LipidomeDB数据计算环境（DCE）是一种用于处理来自脂质直接输注串联质谱仪数据的数据的网络应用程序，由Zhou等人描述（Lipids，46，879 - 884）。原始版本在多个样品上处理多个前体和/或中性损失扫描。LipidomeDB DCE的最新更新（http：//lipidome.bcf.ku.edu：8080/Lipidomics/）扩展了LipidomeDB DCE的功能，以通过直接输注质谱法处理在多反应监测（MRM）模式下采集的数据。前体-中性丢失工作流程和MRM工作流程均删除了由于脂质分析物的同位素重叠以及与内标物相比计算每种靶脂质的量而产生的信号。
LipidomeDB Data Calculation Environment (DCE), a web application for processing data from direct‐infusion tandem mass spectrometer data on lipids, was described by Zhou et al. (, Lipids, 46, 879‐884). The original version processed multiple precursor and/or neutral loss scans on multiple samples. A recent update to LipidomeDB DCE, http://lipidome.bcf.ku.edu:8080/Lipidomics/, extends LipidomeDB DCE's functionality to process data acquired in multiple reaction monitoring (MRM) mode by direct‐infusion mass spectrometry. Both the precursor‐neutral loss workflow and the MRM workflow remove signals due to isotopic overlap of lipid analytes and calculation of the amount of each target lipid in comparison with internal standards.