Quantifying long-term health and economic outcomes for survivors of group B Streptococcus invasive disease in infancy: protocol of a multi-country study in Argentina, India, Kenya, Mozambique and South Africa.
Quantifying long-term health and economic outcomes for survivors of group B Streptococcus invasive disease in infancy: protocol of a multi-country study in Argentina, India, Kenya, Mozambique and South Africa.
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DOI：
10.12688/gatesopenres.13185.1
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发表时间：
2020-01-01
影响因子：
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通讯作者：
Lawn, Joy E
中科院分区：
文献类型：
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作者：
Paul, Proma;Procter, Simon R;Lawn, Joy E
婴儿早期由侵袭性B组链球菌(IGBS)引起的败血症和脑膜炎是导致儿童死亡的主要原因。最近对全球全球IGBS负担的系统估计表明，每年有319,000例婴儿IGBS疾病病例，估计有147,000例死产和幼婴死亡，负担最高的是撒哈拉以南非洲。会议强调了以下优先数据差距：(1)婴儿政府间生物多样性公约的长期成果数据，包括轻度残疾，以计算质量调整寿命年或残疾调整寿命年，以及(2)政府间生态系统幸存者及其家人的经济负担。地理数据差距也被注意到，低收入和中等收入国家(LMIC)的研究很少，因为据估计，这些国家的GBS负担最高。在这篇文章中，我们提出了一项多国家配对队列研究的方案，旨在评估阿根廷、印度、肯尼亚、莫桑比克和南非侵袭性GBS疾病幸存者的长期神经发育障碍(NDI)、社会情绪行为和经济后果的风险。将从健康人口监测系统、医院记录以及以前流行病学研究的参与者中确定儿童的身份。这些孩子的年龄在18个月到17岁之间。一个基于平板电脑的定制应用程序将用于从对儿童的直接评估和与主要照顾者的访谈中捕获数据。此外，一项平行的子研究将前瞻性地衡量新生儿败血症或脑膜炎引起的急性住院费用，而不考虑潜在的病因。总而言之，这些数据对于描述IGBS疾病的后果和推动有效的战略使幸存者能够发挥其发展和经济潜力是必要的。特别是，我们的研究将为制定由世界卫生组织协调的关于孕产妇GBS免疫的全面公共卫生价值主张提供信息。
Sepsis and meningitis due to invasive group B Streptococcus (iGBS) disease during early infancy is a leading cause of child mortality. Recent systematic estimates of the worldwide burden of GBS suggested that there are 319,000 cases of infant iGBS disease each year, and an estimated 147,000 stillbirths and young-infant deaths, with the highest burden occurring in Sub-Saharan Africa. The following priority data gaps were highlighted: (1) long-term outcome data after infant iGBS, including mild disability, to calculate quality-adjusted life years (QALYs) or disability-adjusted life years (DALYs) and (2) economic burden for iGBS survivors and their families. Geographic data gaps were also noted with few studies from low- and middle- income countries (LMIC), where the GBS burden is estimated to be the highest. In this paper we present the protocol for a multi-country matched cohort study designed to estimate the risk of long-term neurodevelopmental impairment (NDI), socioemotional behaviors, and economic outcomes for children who survive invasive GBS disease in Argentina, India, Kenya, Mozambique, and South Africa. Children will be identified from health demographic surveillance systems, hospital records, and among participants of previous epidemiological studies. The children will be aged between 18 months to 17 years. A tablet-based custom-designed application will be used to capture data from direct assessment of the child and interviews with the main caregiver. In addition, a parallel sub-study will prospectively measure the acute costs of hospitalization due to neonatal sepsis or meningitis, irrespective of underlying etiology. In summary, these data are necessary to characterize the consequences of iGBS disease and enable the advancement of effective strategies for survivors to reach their developmental and economic potential. In particular, our study will inform the development of a full public health value proposition on maternal GBS immunization that is being coordinated by the World Health Organization.