Acute interaction between hydrocortisone and insulin alters the plasma metabolome in humans.
Acute interaction between hydrocortisone and insulin alters the plasma metabolome in humans.
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DOI：
10.1038/s41598-017-10200-9
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发表时间：
2017-09-13
影响因子：
4.6
通讯作者：
Watson DG
中科院分区：
文献类型：
--
作者：
Alwashih MA;Stimson RH;Andrew R;Walker BR;Watson DG
为了鉴定糖皮质激素作用的生物标志物及其与胰岛素作用的生物标志物的关系，在来自给予低或中剂量胰岛素输注的20名健康男性（每组n = 10）的血浆样品中进行代谢组学分析。此外，所有受试者在随机交叉设计中给予甲吡酮（抑制肾上腺皮质醇分泌）+ /−氢化可的松（HC），以产生低、中、高糖皮质激素水平。胰岛素最明显的作用是降低支链氨基酸（BCAs）亮氨酸/异亮氨酸及其脱氨基代谢物的血浆水平，并降低游离脂肪酸和酰基肉毒碱。最高剂量的氢化可的松增加了两个胰岛素组的血浆BCAs，但仅在高胰岛素组中增加了游离脂肪酸，然而氢化可的松并不影响两组中酰基肉毒碱的水平。HC和胰岛素之间最明显的相互作用是氢化可的松使BCAs及其代谢物的水平升高，而胰岛素使其降低。糖皮质激素和胰岛素对BCAs的直接调节可能为改善糖皮质激素和胰岛素作用的体内监测提供基础。
With the aim of identifying biomarkers of glucocorticoid action and their relationship with biomarkers of insulin action, metabolomic profiling was carried out in plasma samples from twenty healthy men who were administered either a low or medium dose insulin infusion (n = 10 each group). In addition, all subjects were given metyrapone (to inhibit adrenal cortisol secretion) + /− hydrocortisone (HC) in a randomised crossover design to produce low, medium and high glucocorticoid levels. The clearest effects of insulin were to reduce plasma levels of the branched chain amino acids (BCAs) leucine/isoleucine and their deaminated metabolites, and lowered free fatty acids and acylcarnitines. The highest dose of hydrocortisone increased plasma BCAs in both insulin groups but increased free fatty acids only in the high insulin group, however hydrocortisone did not affect the levels of acyl carnitines in either group. The clearest interaction between HC and insulin was that hydrocortisone produced an elevation in levels of BCAs and their metabolites which were lowered by insulin. The direct modulation of BCAs by glucocorticoids and insulin may provide the basis for improved in vivo monitoring of glucocorticoid and insulin action.
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影响因子：
3.7
作者：
Lucio M;Fekete A;Weigert C;Wägele B;Zhao X;Chen J;Fritsche A;Häring HU;Schleicher ED;Xu G;Schmitt-Kopplin P;Lehmann R
通讯作者：
Lehmann R
DOI：
10.1056/nejmoa1214969
发表时间：
2013-04-18
期刊：
The New England journal of medicine
影响因子：
--
作者：
Boonen E;Vervenne H;Meersseman P;Andrew R;Mortier L;Declercq PE;Vanwijngaerden YM;Spriet I;Wouters PJ;Vander Perre S;Langouche L;Vanhorebeek I;Walker BR;Van den Berghe G
通讯作者：
Van den Berghe G
影响因子：
6.7
作者：
Kawaguchi, Takumi;Taniguchi, Eitaro;Sata, Michio
通讯作者：
Sata, Michio
DOI：
10.1152/ajpgi.00510.2003
发表时间：
2005-06-01
影响因子：
4.5
作者：
Nishitani, S;Takehana, K;Sonaka, I
通讯作者：
Sonaka, I
DOI：
10.1016/s0006-291x(02)02717-1
发表时间：
2002-12-20
影响因子：
3.1
作者：
Nishitani, S;Matsumura, T;Yagasaki, K
通讯作者：
Yagasaki, K