Strategies for the prevention of antimalarial drug resistance: Rationale for combination chemotherapy for malaria
Strategies for the prevention of antimalarial drug resistance: Rationale for combination chemotherapy for malaria
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DOI：
10.1016/0169-4758(96)10055-7
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发表时间：
1996-10-01
期刊：
影响因子：
--
通讯作者：
Olliaro, PL
中科院分区：
文献类型：
--
作者：
White, NJ;Olliaro, PL
在影响人类的几种“热带”疾病中，疟疾带来了特殊的控制问题，因为面临这种疾病风险的人口越来越多，在热带地区消灭蚊子媒介困难重重，以及寄生虫对常用抗疟疾药物的耐药性的出现和传播。临床经验和实验证据都表明，无论最初使用时多么有效，药物的寿命都不可避免地会因耐药寄生虫的出现而缩短。耐药性是决定抗疟药物有效寿命的最重要因素。在这篇综述中，Nick White和Piero Olliaro讨论了联合化疗的基本原理。
Among the several 'tropical' diseases that affect humans, malaria poses special control problems due to the increasing population at risk from the disease, the difficulties in eradicating the mosquito vector in the tropics and the emergence and spread of parasite resistance to commonly used antimalarial drugs. There is both clinical experience and experimental evidence that, however effective when first introduced, the lifespan of drugs is inevitably curtailed by the emergence of resistant parasites. Resistance is the most important factor in determining the useful lifespan of antimalarial drugs. In this' review, Nick White and Piero Olliaro discuss the rationale for combination chemotherapy.