Hippocampal-prefrontal theta phase synchrony in planning of multi-step actions based on memory retrieval
Hippocampal-prefrontal theta phase synchrony in planning of multi-step actions based on memory retrieval
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DOI：
10.1111/ejn.13547
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发表时间：
2017-05-01
影响因子：
3.4
通讯作者：
Sakurai, Yoshio
中科院分区：
文献类型：
--
作者：
Ishino, Seiya;Takahashi, Susumu;Sakurai, Yoshio
基于获取信息的检索的多步骤行动的规划是有效觅食的必要条件。海马（HPC）和前额叶皮质（PFC）在这一过程中可能起着关键作用。然而，在啮齿类动物中，许多研究调查这些角色的研究使用了只需要一步行动的T迷宫任务（即。例如，选择两个选项之一），其中记忆检索和基于检索的动作选择不能明确区分。在猴子，PFC已被建议参与规划的多步行动，然而，HPC和PFC之间的同步性尚未得到评估。为了解决多步行动规划的区域的综合作用，我们在大鼠中引入了一项任务，该任务需要三个连续的鼻子戳响应三个顺序照明的鼻子戳孔。同时记录海马CA 1区和内侧前额叶皮层（mPFC）的局部场电位（LFP）和峰电位。第一个球洞的位置表明接下来的两个球洞是否会以可预测的顺序出现。在第一个鼻子戳期间，在可预测和不可预测的试验之间，区域之间的θ范围（4-10 Hz）中的LFP的相位同步没有不同。然而，只有在可预测序列的试验中，在第一个鼻子戳期间的θ相位同步的幅度与提前两步鼻子戳反应的潜伏期呈负相关。我们的研究结果指出，HPC-mPFC θ相位同步作为一个关键的机制，规划的多步行动的基础上的记忆检索，而不是检索本身。
Planning of multi-step actions based on the retrieval of acquired information is essential for efficient foraging. The hippocampus (HPC) and prefrontal cortex (PFC) may play critical roles in this process. However, in rodents, many studies investigating such roles utilized T-maze tasks that only require one-step actions (i. e., selection of one of two alternatives), in which memory retrieval and selection of an action based on the retrieval cannot be clearly differentiated. In monkeys, PFC has been suggested to be involved in planning of multi-step actions; however, the synchrony between HPC and PFC has not been evaluated. To address the combined role of the regions in planning of multi-step actions, we introduced a task in rats that required three successive nose-poke responses to three sequentially illuminated nose-poke holes. During the task, local field potentials (LFP) and spikes from hippocampal CA1 and medial PFC (mPFC) were simultaneously recorded. The position of the first hole indicated whether the following two holes would be presented in a predictable sequence or not. During the first nose-poke period, phase synchrony of LFPs in the theta range (4-10 Hz) between the regions was not different between predictable and unpredictable trials. However, only in trials of predictable sequences, the magnitude of theta phase synchrony during the first nose-poke period was negatively correlated with latency of the two-step ahead nose-poke response. Our findings point to the HPC-mPFC theta phase synchrony as a key mechanism underlying planning of multi-step actions based on memory retrieval rather than the retrieval itself.