Increased Serum Levels of Epidermal Growth Factor in Children with Autism
Increased Serum Levels of Epidermal Growth Factor in Children with Autism
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DOI：
10.1007/s10803-010-1046-3
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发表时间：
2011-02-01
影响因子：
3.9
通讯作者：
Sener, Sahnur
中科院分区：
文献类型：
--
作者：
Iseri, Elvan;Guney, Esra;Sener, Sahnur
自闭症的病因尚不清楚，但自闭症被认为是一种多因素疾病，受到神经、环境、免疫和遗传因素的影响。表皮生长因子（epidermal growth factor，EGF）是一种重要的生长因子，在中枢和外周神经系统的细胞增殖和分化中起重要作用。在这项研究中，我们假设EGF可能在自闭症的病理生理学中发挥作用，并检查了自闭症儿童的血清EGF水平。我们检测了27名孤独症儿童和28名年龄匹配的正常对照者的血清EGF水平。孤独症患者血清EGF水平显著高于正常对照组。然而，在自闭症患者中，血清EGF水平与临床变量之间没有相关性。这是第一份证明自闭症儿童血清EGF水平升高的报告。这项研究表明，EGF水平的增加可能在自闭症的病理生理学中具有重要意义。
The etiology of autism is unclear, however autism is considered as a multifactorial disorder that is influenced by neurological, environmental, immunological and genetic factors. Growth factors, including epidermal growth factor (EGF), play an important role in the celluler proliferation and the differentiation of the central and peripheral nervous system. In this study we hypothesized that EGF may play a role in the pathophysiology of autism and examined serum EGF levels in children with autism. We measured serum levels of EGF in the 27 autistic children and 28 age- matched normal controls. The serum levels of EGF in the subjects with autism were significantly higher than those of normal control subjects. However, there were no correlations between serum EGF levels and clinical variables in the subjects with autism. This is the first report demonstrating the increased serum levels of EGF in children with autism. This study suggests that increased levels of EGF might have an importance in the pathophysiology of autism.