Cytotoxic Sesterterpenoids Isolated from the Marine Sponge Scalarispongia sp.
Cytotoxic Sesterterpenoids Isolated from the Marine Sponge Scalarispongia sp.
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DOI：
10.3390/ijms151120045
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发表时间：
2014-11-01
影响因子：
5.6
通讯作者：
Yun, Jieun
中科院分区：
文献类型：
--
作者：
Lee, Yeon-Ju;Lee, Jeong-Woo;Yun, Jieun
从海绵Scalaropongia sp.中分离得到8个梯香烷型二萜类化合物，其中4个为新化合物，其结构经2D-NMR和HRMS确证。除16-O-去乙酰基-12，16-表-标量丁醇外，所有分离的化合物对6种人癌细胞系显示出显著的体外细胞毒性（GI 50值低至5.2 μ M）。
Eight scalarane sesterterpenoids, including four new compounds, were isolated from the marine sponge Scalarispongia sp. The structures of the new compounds were elucidated by 2D-NMR and HRMS analyses. All of the isolated compounds, with the exception of 16-O-deacetyl-12,16-epi-scalarolbutanolide, showed significant in vitro cytotoxicity (GI50 values down to 5.2 mu M) against six human cancer cell lines.