Plasma CRP level is positively associated with the severity of COVID-19
Plasma CRP level is positively associated with the severity of COVID-19
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DOI：
10.1186/s12941-020-00362-2
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发表时间：
2020-05-15
影响因子：
5.7
通讯作者：
Qiao, Zengpei
中科院分区：
文献类型：
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作者：
Chen, Wei;Zheng, Kenneth I.;Qiao, Zengpei
2019冠状病毒病（COVID-19）具有高度传染性和致命性;然而，没有可靠和方便的生物标志物来预测疾病的严重程度。本研究的目的是评估CRP水平是否能够作为指示COVID-19严重程度的标志物。方法以咳嗽、胸痛伴或不伴发热为主诉，经实验室qRT-PCR检测SARS-CoV-2病毒核酸确诊的患者为研究对象。然后进行胸部计算机断层扫描（CT），根据中期管理指南将患者分为轻度、中度和重度肺炎组。然后应用线性回归模型分析C反应蛋白（CRP）水平与COVID-19肺炎严重程度之间的关系。结果与轻度肺炎相比，中、重度肺炎的校正比值比分别为11.46，p = 0.029和23.40，p = 0.025。受试者操作曲线下面积为0.898（95% CI 0.835，0.962，p < 0.001）。血浆CRP水平较高表明COVID-19肺炎严重，住院时间较长。结论血浆CRP水平与COVID-19肺炎的严重程度呈正相关。我们的研究结果可以帮助区分中度至重度COVID-19肺炎患者和轻度患者。我们的研究结果可能是有用的，作为一个早期的指标，严重的疾病，并帮助医生分层的病人密集的监护病房转移。
Aims The coronavirus disease 2019 (COVID-19) is characterized as highly contagious and deadly; however there is no credible and convenient biomarker to predict the severity of the disease. The aim of the present study was to estimate whether the CRP level is able to act as a marker in indicating the severity of COVID-19. Methods Patients who complained cough or chest pain with or without fever were enrolled after laboratory confirmed of SARS-CoV-2 viral nucleic acid via qRT-PCR. Chest computed tomography (CT) was then performed to classify the patients into mild, moderate and severe pneumonia groups according to the interim management guideline. Then linear regression models were applied to analyze the association between c-reactive protein (CRP) levels and severity of COVID-19 pneumonia. Results When compared to mild pneumonia, the adjusted-Odds Ratio were 11.46, p = 0.029 and 23.40, p = 0.025 in moderate and severe pneumonia, respectively. The area under receiver operation curve was 0.898 (95% CI 0.835, 0.962, p < 0.001). Higher plasma CRP level indicated severe COVID-19 pneumonia and longer inpatients duration. Conclusions The level of plasma CRP was positively correlated to the severity of COVID-19 pneumonia. Our findings could assist to discern patients of moderate to severe COVID-19 pneumonia from the mild ones. Our findings may be useful as an earlier indicator for severe illness and help physicians to stratify patients for intense care unit transfer.