Color and orientation are jointly coded and spatially organized in primate primary visual cortex
Color and orientation are jointly coded and spatially organized in primate primary visual cortex
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DOI：
10.1126/science.aaw5868
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发表时间：
2019-06-28
期刊：
影响因子：
56.9
通讯作者：
Callaway, Edward M.
中科院分区：
文献类型：
--
作者：
Garg, Anupam K.;Li, Peichao;Callaway, Edward M.
先前的研究支持教科书模型，即形状和颜色是由灵长类初级视觉皮层（V1）的不同神经元提取的。然而，该模型的严格测试需要采样比以前可能的更大的刺激空间。我们使用稳定的GCaMP6f表达和双光子钙成像来探测非常大的空间和彩色视觉刺激空间，并以单细胞分辨率绘制数千个神经元的功能微结构。显著比例的V1神经元强烈喜欢等亮度的颜色，在非彩色刺激，也是方向选择性的，表明方向和颜色在V1相互处理重叠的电路。单个神经元可以精确而明确地编码颜色和方向。进一步的分析揭示了系统的颜色调谐，方向选择性和细胞色素氧化酶组织学之间的空间关系。
Previous studies support the textbook model that shape and color are extracted by distinct neurons in primate primary visual cortex (V1). However, rigorous testing of this model requires sampling a larger stimulus space than previously possible. We used stable GCaMP6f expression and two-photon calcium imaging to probe a very large spatial and chromatic visual stimulus space and map functional microarchitecture of thousands of neurons with single-cell resolution. Notable proportions of V1 neurons strongly preferred equiluminant color over achromatic stimuli and were also orientation selective, indicating that orientation and color in V1 are mutually processed by overlapping circuits. Single neurons could precisely and unambiguously code for both color and orientation. Further analyses revealed systematic spatial relationships between color tuning, orientation selectivity, and cytochrome oxidase histology.