The Mouse Hospital and Its Integration in Ultra-Precision Approaches to Cancer Care.
The Mouse Hospital and Its Integration in Ultra-Precision Approaches to Cancer Care.
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DOI：
10.3389/fonc.2018.00340
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发表时间：
2018
影响因子：
4.7
通讯作者：
Pandolfi PP
中科院分区：
文献类型：
--
作者：
Clohessy JG;Pandolfi PP
精准医学为癌症的治疗带来了真正的希望。调整治疗策略，使患者接受个性化的治疗方案，将改变癌症等疾病的管理方式。分子图谱技术已经提供了前所未有的能力来表征肿瘤，但将其转化为临床上可操作的结果的能力是有限的。为了能够以共同临床的方式将个性化治疗方法实时转换为患者护理，将需要采用和集成促进患者疾病建模的方法。老鼠医院代表了一种非常适合于临床护理的新治疗策略的临床前和共同临床评估的方法。患者衍生异种移植(PDX)技术和使用基因工程小鼠模型(GEMM)的原位肿瘤建模方法已经被证明具有模拟人类肿瘤反应的能力，它们的应用可以通过使用联合临床试验项目和小鼠医院基础设施来镜像人类临床试验，从而为个别患者提供对适当临床方法的宝贵见解。此外，老鼠医院与其他应用精准医疗的新兴技术(包括有机化合物技术)的整合，提供了一个平台，使医疗中心能够真正获得精准医疗必须提供的好处。
Precision medicine holds real promise for the treatment of cancer. Adapting therapeutic strategies so patients receive individualized treatment protocols, will transform how diseases like cancer are managed. Already, molecular profiling technologies have provided unprecedented capacity to characterize tumors, yet the ability to translate this to actionable outcome in the clinic is limited. To enable real time translation of personalized therapeutic approaches to patient care in a co-clinical manner will require the adoption and integration of approaches that facilitate modeling of patient disease. The Mouse Hospital represents an approach that is ideally suited to pre- and co-clinical evaluation of novel therapeutic strategies for clinical care. Patient derived xenograft (PDX) technologies and in situ tumor modeling approaches using genetically engineered mouse models (GEMMs) already have a proven capacity to mimic human tumor responses, and their application can deliver invaluable insights into appropriate clinical approaches for individual patients by mirroring human clinical trials using a Co-Clinical Trial project and Mouse Hospital infrastructure. Additionally, the integration of the Mouse Hospital with other emerging technologies for the application of precision medicines, including organoid technologies, provides a platform that enables medical centers to truly reap the benefits that precision medicine has to offer.
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影响因子：
82.9
作者：
Gao, Hui;Korn, Joshua M.;Sellers, William R.
通讯作者：
Sellers, William R.
影响因子：
64.5
作者：
Basu A;Bodycombe NE;Cheah JH;Price EV;Liu K;Schaefer GI;Ebright RY;Stewart ML;Ito D;Wang S;Bracha AL;Liefeld T;Wawer M;Gilbert JC;Wilson AJ;Stransky N;Kryukov GV;Dancik V;Barretina J;Garraway LA;Hon CS;Munoz B;Bittker JA;Stockwell BR;Khabele D;Stern AM;Clemons PA;Shamji AF;Schreiber SL
通讯作者：
Schreiber SL
影响因子：
16
作者：
Guernet A;Mungamuri SK;Cartier D;Sachidanandam R;Jayaprakash A;Adriouch S;Vezain M;Charbonnier F;Rohkin G;Coutant S;Yao S;Ainani H;Alexandre D;Tournier I;Boyer O;Aaronson SA;Anouar Y;Grumolato L
通讯作者：
Grumolato L
影响因子：
28.2
作者：
Pauli C;Hopkins BD;Prandi D;Shaw R;Fedrizzi T;Sboner A;Sailer V;Augello M;Puca L;Rosati R;McNary TJ;Churakova Y;Cheung C;Triscott J;Pisapia D;Rao R;Mosquera JM;Robinson B;Faltas BM;Emerling BE;Gadi VK;Bernard B;Elemento O;Beltran H;Demichelis F;Kemp CJ;Grandori C;Cantley LC;Rubin MA
通讯作者：
Rubin MA
影响因子：
64.5
作者：
Gao D;Vela I;Sboner A;Iaquinta PJ;Karthaus WR;Gopalan A;Dowling C;Wanjala JN;Undvall EA;Arora VK;Wongvipat J;Kossai M;Ramazanoglu S;Barboza LP;Di W;Cao Z;Zhang QF;Sirota I;Ran L;MacDonald TY;Beltran H;Mosquera JM;Touijer KA;Scardino PT;Laudone VP;Curtis KR;Rathkopf DE;Morris MJ;Danila DC;Slovin SF;Solomon SB;Eastham JA;Chi P;Carver B;Rubin MA;Scher HI;Clevers H;Sawyers CL;Chen Y
通讯作者：
Chen Y