The immunopathology of multiple sclerosis:: An overview
The immunopathology of multiple sclerosis:: An overview
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DOI：
10.1111/j.1750-3639.2007.00064.x
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发表时间：
2007-04-01
期刊：
影响因子：
6.4
通讯作者：
Lucchinetti, Claudia F.
中科院分区：
文献类型：
--
作者：
Lassmann, Hans;Brueck, Wolfgang;Lucchinetti, Claudia F.
多发性硬化症 (MS) 传统上被视为一种炎症性脱髓鞘疾病，其特征是在中枢神经系统白质中形成局灶性脱髓鞘斑块。在这篇综述中，我们描述了最新的证据，表明多发性硬化症病理学的范围要广泛得多。这包括皮质和深层灰质核的脱髓鞘，以及正常白质的弥漫性损伤。不同患者和疾病不同阶段形成局灶性病变的机制以及参与诱导弥漫性脑损伤的机制是复杂且异质的。这种异质性反映在疾病的不同临床表现上，例如复发性或进行性多发性硬化症，并且也至少部分解释了多发性硬化症与其他炎性脱髓鞘疾病的关系。
Multiple sclerosis (MS) is traditionally seen as an inflammatory demyelinating disease, characterized by the formation of focal demyelinated plaques in the white matter of the central nervous system. In this review we describe recent evidence that the spectrum of MS pathology is much broader. This includes demyelination in the cortex and deep gray matter nuclei, as well as diffuse injury of the normal-appearing white matter. The mechanisms responsible for the formation of focal lesions in different patients and in different stages of the disease as well as those involved in the induction of diffuse brain damage are complex and heterogeneous. This heterogeneity is reflected by different clinical manifestations of the disease, such as relapsing or progressive MS, and also explains at least in part the relation of MS to other inflammatory demyelinating diseases.