Proteins and their shape strings
Proteins and their shape strings
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DOI：
10.1109/memb.2005.1436459
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发表时间：
2005-05-01
影响因子：
--
通讯作者：
Kretsinger, RH
中科院分区：
文献类型：
--
作者：
Ison, RE;Hovmöller, S;Kretsinger, RH
本文介绍了一个典型的蛋白质结构的计算机表示。该论文描述了如何通过在表中查找来从形状串（符号序列）描述恢复蛋白质骨架转角的构型，所述形状串描述是压缩和近似的。虽然它们在许多算法中内部使用，但形状字符串通常不被视为人类应该阅读的注释。蛋白质结构在进化中比序列保守得多。形状字符串对人眼来说非常有启发性，应该可以识别出那些在时间的迷雾中序列发生分歧的遥远同源物。
The paper presents an exemplary computer representation of protein structure. The paper described how the configurations of protein backbone turns can be recovered from shape-string (sequence of symbols) descriptions, which are compressed and approximate, by looking them up in a table. Although they are used internally in many algorithms, shape strings are not generally regarded as an annotation that humans should read. Protein structure is much more conserved by evolution than sequence is. Shape strings can be very revealing to the human eye and should identify distant homologues whose sequences have diverged in the fog of time.